[annotation] question about use of 'colocalizes with'

[Rama Balakrishnan]

Hi All,

We have a question about the use of 'colocalizes with' qualifier.

We are curating-

PMID: 16713564

Downregulation of PP2A(Cdc55) phosphatase by separase initiates
mitotic exit in budding yeast.  Queralt E, Lehane C, Novak B, Uhlmann
F. Cell. 2006 May 19;125(4):719-32.

In the section titled " Separase-Dependent Downregulation of PP2ACdc55
at Anaphase Onset" the authors say that 'Colocalization with Net1
revealed nucleolar enrichment of Cdc55 in metaphase'.... (I have
highlighted this section in the attached pdf). The figure legend for
Fig 5A says 'Cdc55 localization in the nucleolus'.

Should Cdc55 be annotated to 'nucleolus' directly or to 'colocalizes
with nucleolus'? The documentation on how to use this qualifier should
be updated with more examples.

  http://www.geneontology.org/GO.annotation.conventions.shtml#colocalizes_with

Thanks for your help,

Rama