[Annotation] false positive IPR domain

[edimmer at ebi.ac.uk]

Yes - these methods have greatly benefited from external curator feedback.

The InterPro2GO mapping resource in particular has been greatly improved
by information passed on from curators from lower eukaryotic/prokaryotic
databases, sometimes there can be an unintentional bias in the mapping
curators have made to domains; as the proteins in UniProt increases so the
validity of the GO mappings to InterPro domains needs to be reviewed.

Thanks!
Emily

>
> For anyone who can't find this  tracker it is here:
>
> https://sourceforge.net/tracker/?atid=605890&group_id=36855&func=browse
>
> If we all consistently submit  our false positives from the mappings when
> spot them, it will rapidly improve the electronic mappings for all
> users..... most incorrect mappings affect many organisms.
>
> However, the mappings (Interpro and Uniprot keywords) are pretty good
> these days though, so perhaps we have almost reached the point where most
> of the false positives have been weeded out already? This should be the
> case for any domains and families which are conserved in yeasts.
>
> Val
>
>
> edimmer at ebi.ac.uk wrote:
>> Hi Doug,
>>
>> Exactly as Rama says, you can add it to the Annotation tracker - and
>> assign it to 'interhelp'.
>>
>> Thanks,
>> Emily
>>
>> > Doug,
>> >
>> > Annotation tracker on SF?
>> >
>> > Rama
>> >
>> > On Aug 18, 2008, at 2:12 PM, Doug howe wrote:
>> >
>> >> To whom should we direct inquiries about false positive interpro
>> >> domain hits?  The alleged false positive is percolating through to
>> >> our GO annotations and causing spurious interpro2go translations I
>> >> think.
>> >>
>> >> --
>> >> Doug Howe, Ph.D.
>> >> ZFIN Scientific Curator
>> >> Zebrafish Nomenclature Coordinator
>> >>
>> >> _______________________________________________
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>> >> Annotation at geneontology.org
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>> >
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>> >
>>
>>
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>
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