[annotation] question about use of 'colocalizes with'

[Rama Balakrishnan]

reposting...

rama

On Dec 19, 2007, at 12:50 PM, Rama Balakrishnan wrote:

>
> Hi All,
>
> We have a question about the use of 'colocalizes with' qualifier.
>
> We are curating-
>
> PMID: 16713564
>
> Downregulation of PP2A(Cdc55) phosphatase by separase initiates
> mitotic exit in budding yeast.  Queralt E, Lehane C, Novak B, Uhlmann
> F. Cell. 2006 May 19;125(4):719-32.
>
> In the section titled " Separase-Dependent Downregulation of PP2ACdc55
> at Anaphase Onset" the authors say that 'Colocalization with Net1
> revealed nucleolar enrichment of Cdc55 in metaphase'....

> The figure legend for
> Fig 5A says 'Cdc55 localization in the nucleolus'.
>
> Should Cdc55 be annotated to 'nucleolus' directly or to 'colocalizes
> with nucleolus'? The documentation on how to use this qualifier should
> be updated with more examples.
>
>   http://www.geneontology.org/ 
> GO.annotation.conventions.shtml#colocalizes_with
>
> Thanks for your help,
>
> Rama