[Annotation] strange chicken-rabbit mutant hybrid: annotation?

[Petra Fey]

Hi Fiona,

I think this should both be IPI:

GO:0005523 tropomyosin binding  FOR the rabbit TNNT3 WITH the chicken  
TmI
GO:0031014 troponin T binding FOR the chicken TmI WITH the rabbit TNNT3

Cheers,
Petra


Petra Fey
dictyBase Curator
http://dictybase.org


On Jul 1, 2008, at 10:50 AM, Fiona McCarthy wrote:

> Hi All,
>
> I'm annotating a paper about chicken troponin T (PMID:9774396). In  
> one of
> the experiments that authors show chicken tropomyosin I (TmI)  
> binding to
> rabbit troponin T (TNNT3).
>
> The two functions here are:
> GO:0005523 tropomyosin binding for the rabbit TNNT3
> GO:0031014 troponin T binding for the chicken TmI
>
> The authors don't mention making a strange mutant hybrid chicken/ 
> rabbit (a
> raben? a chickbit?) and their intent was to assay binding activity.
>
> Should this be IDA? A chicken protein binding a rabbit protein seems  
> wrong
> for IDA.
>
> Fiona
>
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