[Annotation] gain of function mutants

[Doug howe]

Do you curate GO from gain of function mutants like Tg lines that 
express a gene in a tissue specific fashion?  Sometimes this seems 
appropriate if the gene being expressed is normally present in the 
tissues being examined at the time of development when the Tg is 
active.  In other cases it seems like the Tg is just a tool to study a 
pathway or something.  For example authors want to study the role of bmp 
signaling in heart development so the express bmp2b in the cardiac 
progenitors.  If this has an effect on heart development, do you 
annotate bmp2b as such or not?  Likewise if they express nog3 (a bmp 
signaling antagonist).  If nog3 expression has an effect upon heart 
development do you annotate nog3 as such? 

-- 
Doug Howe, Ph.D.
ZFIN Scientific Curator
Zebrafish Nomenclature Coordinator