[Annotation] gain of function mutants

[Tanya Berardini]

Hi Doug,

These gof lines are tissue-specific overexpressing lines, yes?  If the
authors are looking to see what the 'normal' function of the gene is by
overexpression in the tissue where it usually is expressed, then I'd
annotate based on the results in that line.  However, if they're
overexpressing in a whole bunch of places just to see what funky things
happen, I'd be less likely to annotate.

So...is bmp2b normally expressed in cardiac progenitors?  What about nog3?

Tanya

On Fri, Jun 6, 2008 at 12:36 PM, Doug howe <dhowe at cs.uoregon.edu> wrote:

> Do you curate GO from gain of function mutants like Tg lines that express a
> gene in a tissue specific fashion?  Sometimes this seems appropriate if the
> gene being expressed is normally present in the tissues being examined at
> the time of development when the Tg is active.  In other cases it seems like
> the Tg is just a tool to study a pathway or something.  For example authors
> want to study the role of bmp signaling in heart development so the express
> bmp2b in the cardiac progenitors.  If this has an effect on heart
> development, do you annotate bmp2b as such or not?  Likewise if they express
> nog3 (a bmp signaling antagonist).  If nog3 expression has an effect upon
> heart development do you annotate nog3 as such?
> --
> Doug Howe, Ph.D.
> ZFIN Scientific Curator
> Zebrafish Nomenclature Coordinator
>
> _______________________________________________
> Annotation mailing list
> Annotation at geneontology.org
> http://fafner.stanford.edu/mailman/listinfo/annotation
>



-- 
Tanya Berardini
TAIR Curator
www.arabidopsis.org
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://fafner.stanford.edu/pipermail/annotation/attachments/20080609/545decd2/attachment-0001.html>