[Annotation] ligands, receptors, and signaling pathways

[Jennifer Deegan (nee Clark)]

Hi Doug,

I'm starting to overhaul the signaling terms just now. I'll make a note 
of this for when I get down that far.

Thanks,

Jen

Doug howe wrote:

> Is it correct to annotate receptors with signaling pathway terms?  For 
> example if a BMP receptor mutant is shown to have reduced bmp signaling, 
> should the receptor gene be annotated with the term 'BMP signaling 
> pathway', or are receptors themselves not part of the pathway?  Ditto 
> for ligands.
> 
> The current def of 'BMP signaling pathway' is: A series of molecular 
> signals generated as a consequence of any member of the BMP (bone 
> morphogenetic protein) family binding to a cell surface receptor."
> 
> This def makes it seem like the signaling pathway initiates with things 
> downstream of (and excluding) the receptor itself?
> 
> Whatever the policy is on this, it might be a useful curatorial note to 
> include on such terms so curators can see the info right in term browsers.
> 

-- 
Jennifer Deegan (nee Clark)
EMBL-European Bioinformatics Institute
Gene Ontology Consortium