[Annotation] ligands, receptors, and signaling pathways

[Valerie Wood]

Hi Doug,

I have annotated receptors  to signal transduction (or one of its 
children) but not to the signaling pathway itself. I'd also like to know 
if this is correct.
I seem to remember that this was a previous consensus, but I find it 
documented anywhere.

Val



Jennifer Deegan (nee Clark) wrote:
> Hi Doug,
>
> I'm starting to overhaul the signaling terms just now. I'll make a 
> note of this for when I get down that far.
>
> Thanks,
>
> Jen
>
> Doug howe wrote:
>
>> Is it correct to annotate receptors with signaling pathway terms?  
>> For example if a BMP receptor mutant is shown to have reduced bmp 
>> signaling, should the receptor gene be annotated with the term 'BMP 
>> signaling pathway', or are receptors themselves not part of the 
>> pathway?  Ditto for ligands.
>>
>> The current def of 'BMP signaling pathway' is: A series of molecular 
>> signals generated as a consequence of any member of the BMP (bone 
>> morphogenetic protein) family binding to a cell surface receptor."
>>
>> This def makes it seem like the signaling pathway initiates with 
>> things downstream of (and excluding) the receptor itself?
>>
>> Whatever the policy is on this, it might be a useful curatorial note 
>> to include on such terms so curators can see the info right in term 
>> browsers.
>>
>


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Valerie Wood			 Tel: 01223 496909
S. pombe Genome Project		 Fax: 01223 494919 		       
Wellcome Trust Sanger Institute	 email: val at sanger.ac.uk
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