[Annotation] [Gohelp] GO term for "anti-adaptor" protein

[Eurie Hong]

Hi Ingrid,

I'm cc'ing your question to the annotation mailing list.  There are  
many GO curators who annotate a wide range of species on this mailing  
list so this is probably the best list for you to email regarding  
annotation questions.

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Cheers,
Eurie

On Apr 30, 2008, at 2:27 PM, Ingrid Keseler wrote:

> Hi everyone,
>
> I'm having a difficult time identifying an appropriate GO function  
> term
> to annotate a set of small so-called "anti-adaptor" proteins in E.
> coli.  Here's what they do: under normal conditions, a protein called
> RssB binds to the alternative sigma factor, sigmaS, and targets it for
> degradation by the ClpXP protease.  Under certain environmental
> conditions, e.g. phosphate starvation, DNA damage etc., certain small
> proteins (IraP, IraD, IraM) are expressed; they bind to RssB, thus
> (maybe just by competition) preventing it from binding to sigmaS, and
> therefore sigmaS accumulates.  For illustration, see Fig. 6 in PMID
> 18383615 or Fig. 6 in PMID 16600914 (free access).  What would you  
> call
> that function?  I already have GO:0005515 protein binding for the
> interaction with RssB, but that doesn't convey the actual function.   
> For
> process, I am using GO:0042177, negative regulation of protein  
> catabolic
> process.
>
> Any ideas?  Thanks!
>
> -Ingrid
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