[Annotation] IMP or IGI for deficiencies

[Karen Christie]

Hi,

I think I'd be likely to use IGI for a "a deficiency mutant which is known 
to affect more than one gene", barring some extenuating circumstance.

Generally, I use IMP for a single mutant affecting the gene of interest, 
and IGI for most other genetic situations I can think of, e.g. double or 
triple mutants, or a single mutant NOT in the gene being annotated (as per 
GO guidelines which specify that making an annotation for gene A based on 
a single mutation in gene B is IGI).

-Karen

On Fri, 7 Nov 2008, Doug howe wrote:

> If an experiment uses a deficiency mutant which is known to affect more than 
> one gene, should that be curated for GO using IMP or IGI?  Contrast that with 
> basically the same experiment where the same genes were targeted individually 
> with morpholinos/antisense techniques...the latter seems like IGI.
> ?
>
> -- 
> Doug Howe, Ph.D.
> ZFIN Scientific Curator
> Zebrafish Nomenclature Coordinator
>
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