[Annotation] IMP or IGI for deficiencies

[Doug howe]

Hi Karen,
   If a deficiency affects multiple gene, making any annotation is of 
course dependent upon your ability to discern which gene(s) may be 
involved in whatever you are annotating.  I guess it would typically be 
difficult to make any annotation with a Df mutant for that reason.  
There are a few cases in zebrafish where a phenotype was rescued by 
re-introducing specific genes that were lost in the Df..so you at least 
think you know what gene to annotate.

-Doug

Karen Christie wrote:
> Hi,
>
> I think I'd be likely to use IGI for a "a deficiency mutant which is 
> known to affect more than one gene", barring some extenuating 
> circumstance.
>
> Generally, I use IMP for a single mutant affecting the gene of 
> interest, and IGI for most other genetic situations I can think of, 
> e.g. double or triple mutants, or a single mutant NOT in the gene 
> being annotated (as per GO guidelines which specify that making an 
> annotation for gene A based on a single mutation in gene B is IGI).
>
> -Karen
>
> On Fri, 7 Nov 2008, Doug howe wrote:
>
>> If an experiment uses a deficiency mutant which is known to affect 
>> more than one gene, should that be curated for GO using IMP or IGI?  
>> Contrast that with basically the same experiment where the same genes 
>> were targeted individually with morpholinos/antisense 
>> techniques...the latter seems like IGI.
>> ?
>>
>> -- 
>> Doug Howe, Ph.D.
>> ZFIN Scientific Curator
>> Zebrafish Nomenclature Coordinator
>>
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>

-- 
Doug Howe, Ph.D.
ZFIN Scientific Curator
Zebrafish Nomenclature Coordinator