[Annotation] spindle pole annotations

Petra Fey pfey at northwestern.edu
Tue Nov 11 15:02:57 PST 2008


Hello All,

I'm curating a Dicty paper (PMID: 18326585) where they describe  
localization auf dicty Aurora kinase at the outer (cytosolic) side of  
the spindle during prometa- and metaphase, and later, in anaphase, to  
the inner (nuclear) spindle pole. The inner and outer spindle pole  
terms are currently as follows:

% GO:0000922 : spindle pole
%% GO:0005816 : spindle pole body
%%% GO:0005824 : outer plaque of spindle pole body
%%% GO:0005822 : inner plaque of spindle pole body

I cannot annotate to the inner or outer terms as they are yeast  
specific under their parent. GO:0005816 (spindle pole body): The  
microtubule organizing center in fungi; functionally homologous to the  
animal cell centrosome.

In the paper a legend of Fig. 4 also says: "The DdAurora on the inner  
side of the poles represents protein associated with centromers". So  
maybe it's ok just annotate to 'spindle pole' and centrosome (which I  
did) and no annotations to outer and inner? Or do we need new, direct  
children of spindle pole?

% GO:0000922 : spindle pole
%% GO NEW: outer spindle pole (cytosolic)
%% GO NEW: inner spindle pole (nuclear)

What is the opinion of mitotic cycle pros?

Thanks,
Petra


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