[Annotation] check for ND + additional annotation
Midori Harris
midori at ebi.ac.uk
Thu Sep 4 04:51:59 PDT 2008
I think the user said there was an RCA annotation; anyway, it was S.c.
CWC32.
m
On Thu, 4 Sep 2008, Pascale Gaudet wrote:
> Midori,
>
> Were those ND found with IEAs or with other evidence codes?
>
> I also wonder, what happens in cases where there is no literature but other evidence for
> annotations, such as ISS, IGC, etc, if the ND means no experimental data?
>
> Pascale
>
> Midori Harris wrote:
> The reason I brought it up is that apparently not all users appreciate the
> distinction between "no literature" and "no data of any kind". The fact that
> we've named the code "ND" contributes a bit to that confusion. More importantly,
> the documentation that Mike quoted says "no information", and it's perhaps not
> surprising that the user didn't translate that to "no experimental data/no
> literature".
>
> While this exchange has pointed out good reasons for retaining both ND and
> computational annotations, I do think the documentation needs to be clarified.
>
> m
>
> On Wed, 3 Sep 2008, Harold Drabkin wrote:
>
> We also allow IEA along with ND as ND means no literature. Also, we
> have triggers in our Editorial Interface that
> 1. removes ND to an aspect when a non IEA is entered.
> 2. prevents an ND being added if a non-IEA exits for the gene.
>
> We have various qc's operating based on the ND status of a gene and
> if new literature comes in that is indexed to the gene, etc.
> The users need to be made more aware that the ND specifically means
> no literature known to support higher annotations at the time.
>
> h
>
> Pascale Gaudet wrote:
> That seems to make sense. Otherwise, how do you know a
> curator has reviewed the literature for that gene?
>
> Stacia Engel wrote:
> > the gene in question was a yeast gene, CWC23. there is
> ND to generic BP > because we have no experimental data
> for that gene.
> >
> > the gene has computational annotations from both
> UniProtKB and bioPIXIE. at > SGD, we don't remove NDs to
> root nodes when only computational annotations exist.
> >
> > stacia
> >
> >
> > On Sep 3, 2008, at 11:37 AM, Judith Blake wrote:
> >
> >> Typically, I think this should be done at the time of
> generating the >> annotation...even an IEA. Each group
> might consider implementing something >> to QC this, but
> a QC at the time of submission of data file to AmiGO
> would be >> good too.
> >>
> >> Judy
> >>
> >>
> >>
> >> Midori Harris wrote:
> >>> Hi,
> >>>
> >>> We received a query on the GO Help list from a user
> who noticed a gene that >>> was annotated to both the
> biological process (BP) root with ND, and >>> annotated
> to a non-root BP term with another evidence code. I
> agreed with >>> him that it doesn't make sense to keep
> the ND/root annotation if a "real"
> >>> annotation could be made to a term in the same
> ontology. Would it be >>> worthwhile to add a check for
> cases like this, perhaps in Mike's script?
> >>>
> >>> cheers,
> >>> midori
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