[Annotation] cardiac conduction terms
Ceri Van Slyke
van_slyke at uoneuro.uoregon.edu
Fri Jan 16 14:34:45 PST 2009
Hi Everyone,
I am trying to annotate a paper about cardiac conduction and cannot
figure out what GO terms to use. I think the terms should be under
regulation of cardiac muscle contraction but I am not a specialist
and am not sure which terms correspond to the phenotypes I would like
to use as the basis of my IMP annotations.
I have descriptions of the mutants from the paper such as:
Ventricular conduction absent
ventricular conduction disorganized
Atrioventricular conduction block present
Atrioventricular conduction delay absent
Atrial and ventricular fibrillation
The phenotypes were determined by looking at calcium activation.
I know from the paper that there is a fast conduction system in the
ventricle and this system involves the endocardium, there is a
regulation point for conduction between the atrium and ventricle
where a delay is introduced. They also talk about a pacemaker
function in the slow conduction pathway.
These descriptions seem to be intermediate between regulation of
cardiac muscle contraction and the membrane depolarization leaf terms.
I don't have enough information to determine if there is a problem
with depolarization or repolarization. Am I missing any BP terms
that I could be using? Do we need cardiac conduction terms in GO?
Thanks,
Ceri
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