[Annotation] cardiac conduction terms

Ceri Van Slyke van_slyke at uoneuro.uoregon.edu
Fri Jan 16 14:34:45 PST 2009


Hi Everyone,
I am trying to annotate a paper about cardiac conduction and cannot 
figure out what GO terms to use.   I think the terms should be under 
regulation of cardiac muscle contraction but I am not a specialist 
and am not sure which terms correspond to the phenotypes I would like 
to use as the basis of my IMP annotations.


I have descriptions of the mutants from the paper such as:
Ventricular conduction  absent
ventricular conduction disorganized
Atrioventricular conduction block present
Atrioventricular conduction delay absent
Atrial and ventricular fibrillation

The phenotypes were determined by looking at calcium activation.

I know from the paper that there is a fast conduction system in the 
ventricle and this system involves the endocardium,  there is a 
regulation point for conduction between the atrium and ventricle 
where a delay is introduced.    They also talk about a pacemaker 
function in the slow conduction pathway.

These descriptions seem to be intermediate between regulation of 
cardiac muscle contraction and the membrane depolarization leaf terms.
I don't have enough information to determine if there is a problem 
with depolarization or repolarization.  Am I missing any BP terms 
that I could be using?  Do we need cardiac conduction terms in GO?


Thanks,
Ceri



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