[Annotation] filtering IEA translations?

[David Hill]

I think we should remove the translation. When we originally made these 
translation table, we used the very conservative rule that if we could 
find an exception to the translation being correct, we would remove it. 
Otherwise, erroneous data may be generated for organisms that don't have 
experimental support.

David

Doug wrote:
> For groups that apply interpro2go, spkw2go, or ec2go translation files:
>
> If a translation from interpro2go for example takes you to a GO term 
> which is directly contradictory to an experimentally supported 
> annotation in your database, do you apply the IEA annotation or do you 
> filter it out?
>
> Example:
>     We have an IPI annotation to NOT beta-catenin binding and an IEA 
> annotation (translation of InterPro:IPR009428) to 'beta-catenin 
> binding' on our lzic gene.  Should such an IEA annotation be made when 
> it conflicts with experimental annotations?
>
> I see no problem as long as the evidence code is taken into 
> account...what do others think?
>
> -Doug
>
> Doug Howe, Ph.D.
> Scientific Curator
> Zebrafish Nomenclature Coordinator
> Zebrafish Information Network
> 541-346-0120
> dhowe at cs.uoregon.edu
>
>
>
> _______________________________________________
> Annotation mailing list
> Annotation at geneontology.org
> http://fafner.stanford.edu/mailman/listinfo/annotation

-- 
David P. Hill, Ph.D.
Bioinformatics Scientist: Ontology Development
Gene Ontology Consortium
The Jackson Laboratory
www.geneontology.org
www.informatics.jax.org
tel:207-288-6430