[Annotation] filtering IEA translations?

[Karen Christie]

Hi Doug,

SGD doesn't filter any of the IEAs either. But when I see IEAs that look 
incorrect, e.g. they come from an InterPro domain mapping and it is known 
that the SGD protein has or is related to that domain, but it is also 
pretty clear that it doesn't have the suggested activity, I submit items 
on teh Annotation Tracker about the issue, so that either the mapping, or 
maybe the INterPro domain can be improved.

-Karen


On Thu, 12 Mar 2009, Ranjana Kishore wrote:

> Hi Doug,
> We don't filter out any annotations at this point.  We clearly mark 
> annotations as manual or from InterPro2GO mapping or whatever.  Recently on 
> our display page, we even made the groupings of "Based on Experiment" and 
> "Predicted". 
> I don't see a problem as long as evidences are clear, as you point out.
>
> --Ranjana
>
> Doug wrote:
>> For groups that apply interpro2go, spkw2go, or ec2go translation files:
>> 
>> If a translation from interpro2go for example takes you to a GO term which 
>> is directly contradictory to an experimentally supported annotation in your 
>> database, do you apply the IEA annotation or do you filter it out?
>> 
>> Example:
>>     We have an IPI annotation to NOT beta-catenin binding and an IEA 
>> annotation (translation of InterPro:IPR009428) to 'beta-catenin binding' on 
>> our lzic gene.  Should such an IEA annotation be made when it conflicts 
>> with experimental annotations?
>> 
>> I see no problem as long as the evidence code is taken into account...what 
>> do others think?
>> 
>> -Doug
>> 
>> Doug Howe, Ph.D.
>> Scientific Curator
>> Zebrafish Nomenclature Coordinator
>> Zebrafish Information Network
>> 541-346-0120
>> dhowe at cs.uoregon.edu
>> 
>> 
>> 
>> _______________________________________________
>> Annotation mailing list
>> Annotation at geneontology.org
>> http://fafner.stanford.edu/mailman/listinfo/annotation
>
> _______________________________________________
> Annotation mailing list
> Annotation at geneontology.org
> http://fafner.stanford.edu/mailman/listinfo/annotation
>