[ 1219711 ] establishment and/or maintenance of cell polarity

[J Clark]

Hi Rex,

I was assuming that the cell polarity was established by the action of a protein 
or RNA creating a reference point at one end of the cell. I assumed that having 
established which end of the cell was which, the characteristics of the cell 
would be organised relative to the point of reference. The organisation of the 
characteristics of the cell might be mediated by the cytoskeleton but I would 
have thought that the establishment and maintenance of cell polarity would have 
been independant of the cytoskeleton. Would this be right? The only actual 
example of this level of detail that I know is the Drosophila egg, and I'd be 
interested to hear about other example that people are aware of. I don't know so 
much about polarity in single cells.

Thanks,

Jen

Chisholm, Rex FSM wrote:

> It is certainly true that cell polarity is a consequence of cytoskeleton
> organization. What type of relationship would you suggest between cell
> polarity and cytoskeleton organization?  I think it is important to
> capture this.
> 
> Rex
> 
> -----Original Message-----
> From: owner-development at genome.stanford.edu
> [mailto:owner-development at genome.stanford.edu] On Behalf Of J Clark
> Sent: Monday, June 13, 2005 8:54 AM
> To: development
> Subject: [ 1219711 ] establishment and/or maintenance of cell polarity
> 
> Hi,
> 
> Does anybody have views on this?
> 
> [ 1219711 ] establishment and/or maintenance of cell polarity
> https://sourceforge.net/tracker/index.php?func=detail&aid=1219711&group_
> id=36855&atid=440764
> 
> text:
> 
> establishment and/or maintenance of cell polarity ; GO:0007163
> def: The specification, formation and maintenance of anisotropic
> intracellular organization or cell growth patterns.
> 
> is currently an is_a child of cytoskeleton organization and biogenesis ;
> GO:0007010
> def: The assembly and arrangement of cytoskeletal structures.
> 
> and a part_of child of
> 
> cellular morphogenesis ; GO:0000902
> 
> 
> The is_a parentage doesn't seem right to me and I'd like to remove it.
> Would anybody have any objections to that?
> 
> 
> Thanks,
> 
> Jen
> 
> --
> EMBL - European Bioinformatics Institute, Gene Ontology Consortium, and
> Wolfson College, Cambridge.
> http://www.ebi.ac.uk/~jclark/
> 

-- 
EMBL - European Bioinformatics Institute,
Gene Ontology Consortium,
and Wolfson College, Cambridge.
http://www.ebi.ac.uk/~jclark/