Growth and development

J Clark jclark at ebi.ac.uk
Thu Jun 16 01:58:36 PDT 2005


Hi David,

Yes I see what you mean.

Currently we have

[i]cellular physiological process
---[i]cell division
---[i]cell proliferation

cell division
def: The processes resulting in the physical partitioning 
and separation of a cell into daughter cells.

cell proliferation
def: The multiplication or reproduction of cells, resulting 
in the rapid expansion of a cell population.

This could become:

[i]cellular physiological process
---[i]cell proliferation
------[p]cell division


cell proliferation
def: The multiplication or reproduction of cells, occuring 
as a consequence of multiple cell division events, resulting 
in the expansion of a cell population.


That way we lose the word 'rapid', but keep the distinction 
between cell division and cell proliferation.

Would that seem like a plan? I'll post it in the sourceforge 
item.

Thanks,

Jen














David Hill wrote:

> Hi Jen,
> 
> The structure at the bottom looks good to me. I can't really think of 
> how to deal with the multiple part-of relationships, but I think they 
> are true. As for cell proliferation, I don't think it really matters if 
> the word rapid is in the definition or not, since everyone can have a 
> different view of rapid. I think the distinction between cell 
> proliferation and cell division is a difference between an individual 
> cell and a generic representation of cells. In that way, cell division 
> could be a part of cell proliferation.
> 
> 
> David
> 
> J Clark wrote:
> 
>> Hi Pascale,
>>
>> I've put in a new sourceforge request to get comments on that and I'll 
>> implement in a week if nobody objects.
>>
>> 1219649    cell proliferation
>> https://sourceforge.net/tracker/index.php?func=detail&aid=1219649&group_id=36855&atid=440764 
>>
>>
>> Thanks,
>>
>> Jen
>>
>> Pascale Gaudet wrote:
>>
>>> This all looks good to me.
>>>
>>> One other thing is about the definition of cell proliferation, which 
>>> currently is "The multiplication or reproduction of cells, resulting 
>>> in the rapid expansion of a cell population." Can we remove "rapid"? 
>>> and have "The multiplication or reproduction of cells, resulting in 
>>> the expansion of a cell population."
>>> ??
>>>
>>> (this may be relevant for people not on the development list)
>>>
>>> Pascale
>>>
>>>
>>> At 05:12 PM 6/10/2005 +0100, J Clark wrote:
>>>
>>>> Growth and Development proposal:
>>>>
>>>> 1) The term growth will be moved out from under development to be a 
>>>> sibling instead.
>>>>
>>>> Current structure:
>>>>
>>>> [i]development
>>>> ---[i] growth
>>>>
>>>> With new structure:
>>>>
>>>> [i]biological process
>>>> ---[i]growth
>>>> ---[i]development
>>>>
>>>> 2) integrate new concepts:
>>>>
>>>> Term:developmental growth of a unicellular organism
>>>> def: The growth of a single celled organism prior to division, where 
>>>> growth is aimed at the progression of the organism over time from 
>>>> one condition to another.
>>>>
>>>> term: non-developmental growth of a unicellular organism
>>>> def: The growth of a single celled organism prior to division, where 
>>>> the growth does not change the organism from  one condition to 
>>>> another condition over time.
>>>>
>>>> Term: developmental growth
>>>> def: The increase in size or mass of an entire organism, a part of 
>>>> an organism or a cell, where the increase in size or mass is aimed 
>>>> at the progression of the organism over time from one condition to 
>>>> another.
>>>>
>>>> Term: non-developmental growth
>>>> def: The increase in size or mass of an entire organism, a part of 
>>>> an organism or a cell, where the increase in size or mass is not 
>>>> aimed at the progression of the organism over time from one 
>>>> condition to another.
>>>>
>>>> [i]biological process ; GO:0000004
>>>> ---[i]development ; GO:0007275
>>>> ------[p]cell development ; GO:0048468
>>>> ---------[p]developmental growth of a unicellular organism ; GO:new
>>>> ------[p]developmental growth ; GO:new
>>>> ---------[i]developmental growth of a unicellular organism ; GO:new
>>>> ---[i]growth ; GO:0040007
>>>> ------[i]non-developmental growth ; GO:new
>>>> ---------[i]non-developmental growth of a unicellular organism ; GO:new
>>>> ------[i]developmental growth ; GO:new
>>>> ---------[i]developmental growth of a unicellular organism ; GO:new
>>>> ------[i]cell growth ; GO:0016049
>>>> ---------[i]developmental growth of a unicellular organism ; GO:new
>>>> ---------[i]non-developmental growth of a unicellular organism ; GO:new
>>>>
>>>> also
>>>>
>>>> [i]cellular physiological process ; GO:0050875
>>>> ---[i]cell proliferation ; GO:0008283
>>>> ------[p]developmental growth of a unicellular organism ; GO:new
>>>> ------[p]non-developmental growth of a unicellular organism ; GO:new
>>>>
>>>>
>>>> This additional parentage means that
>>>>
>>>> developmental growth of a unicellular organism ; GO:new
>>>>
>>>> is part_of both
>>>>
>>>> cell proliferation ; GO:0008283
>>>>
>>>> and
>>>>
>>>> cell development ; GO:0048468
>>>>
>>>> and terms are not allowed to have to part_of parents.
>>>> I don't see a way out of that right now.
>>>>
>>>> Does anybody have any thoughts on that?
>>>>
>>>> Thanks,
>>>>
>>>> Jen
>>>>
>>>>
>>>>
>>>>
>>>>
>>>
>>
> 
> 



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