vascular system development vs. vasculature development

J Clark jclark at ebi.ac.uk
Thu Apr 27 02:26:18 PDT 2006


>> GO currently has a term 'vasculature development' (GO:0001944) which 
>> is a child of 'organ development'...but GO has no term "vascular 
>> system development' as a child of 'system development'.
>>
>> A few questions follow from this:
>>
>> 1. Should a new term exist for 'vascular system development', and if 
>> so...how is it different from 'vasculature development'?

Vasculature development is defined:

'The process whose specific outcome is the progression of the 
vasculature over time, from its formation to the mature structure.'

which seems to me as if it could just as easily be the vascular system 
development term if we wanted it to be. The system development term was 
only made very recently so there may be more system development terms 
that exist or could exist and have not yet been put in their proper place.

>> 3. In fish, the vascular system develops from a structure named the 
>> 'vascular cord', formed by aggregation of angioblast cells along the 
>> embryonic midline.  If a mutation disrupts formation of this 'vascular 
>> cord', would that gene be annotated to a new term 'vascular cord 
>> development' (with what parentage?), or would it be annotated to 
>> 'vascular system development'..or maybe 'vasculature development'?

I think either would be fine.

Annotation to vascular cord development would be more specific. We could 
make a term 'vascular cord formation' if that would be better.

[i]vascular cord development
---[p] vascular cord morphogenesis
------[p] vascular cord formation

vascular cord formation
def: The process that gives rise to the vascular cord. This process 
pertains to the initial formation of the structure by aggregation of 
angioblast cells along the embryonic midline.

Jen






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