From gocvs at genome.Stanford.EDU Thu Nov 1 21:30:43 2007 From: gocvs at genome.Stanford.EDU (Remote CVS for Gene Ontology) Date: Thu, 1 Nov 2007 21:30:43 -0700 (PDT) Subject: [go-diff] GO update 11/01/2007 Message-ID: <200711020430.VAA18530@bread.Stanford.EDU> OBODIFF of gene_ontology_edit.obo version 5.533 by 5.534 Starting obodiff at /share/go/bin/oboedit/current using 256M of memory * Created object of type obo:TERM with id GO:0060176 * Created object of type obo:TERM with id GO:0060177 * Populated new object GO:0060176 (macro) * Changed name of GO:0060176 from "" to "regulation of aggregation involved in sorocarp development" * Set definition of GO:0060176 to "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." * Added definition dbxref GOC:dph to GO:0060176 * Added definition dbxref GOC:tb to GO:0060176 * Copied GO:0060176 to GO:0031156 with type OBO_REL:is_a * Copied GO:0060176 to GO:0031152 with type part_of * Assigned namespace "biological_process" to GO:0060176 * Populated new object GO:0060177 (macro) * Changed name of GO:0060177 from "" to "regulation of angiotensin metabolic process" * Set definition of GO:0060177 to "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin." * Added definition dbxref GOC:dph to GO:0060177 * Added definition dbxref GOC:tb to GO:0060177 * Added synonym "regulation of angiotensin metabolism" to GO:0060177 * Changed synonym scope of GO:0060177 from "Related" to "Exact" * Copied GO:0060177 to GO:0051246 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0060177 * Deleted GO:0002002 --OBO_REL:is_a--> GO:0019222 * Copied GO:0002002 to GO:0065008 with type OBO_REL:is_a * Copied GO:0002002 to GO:0060177 with type OBO_REL:is_a * Changed name of GO:0015813 from "glutamate transport" to "L-glutamate transport" * Changed definition of GO:0015813 from "The directed movement of glutamate, the anion of 2-aminopentanedioic acid, into, out of, within or between cells." to "The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of, within or between cells." * Added definition dbxref GOC:dph to GO:0015813 * Added definition dbxref GOC:tb to GO:0015813 * Deleted GO:0031157 --OBO_REL:is_a--> GO:0031156 * Deleted GO:0031157 --part_of--> GO:0031152 * Copied GO:0031157 to GO:0060176 with type OBO_REL:is_a * Copied GO:0031157 to GO:0065008 with type OBO_REL:is_a * Changed synonym scope of GO:0051091 from "Narrow" to "Exact" From gocvs at genome.Stanford.EDU Fri Nov 2 21:30:46 2007 From: gocvs at genome.Stanford.EDU (Remote CVS for Gene Ontology) Date: Fri, 2 Nov 2007 21:30:46 -0700 (PDT) Subject: [go-diff] GO update 11/02/2007 Message-ID: <200711030430.VAA02917@bread.Stanford.EDU> OBODIFF of gene_ontology_edit.obo version 5.534 by 5.536 Starting obodiff at /share/go/bin/oboedit/current using 256M of memory * Created object of type obo:TERM with id GO:0010453 * Created object of type obo:TERM with id GO:0010454 * Created object of type obo:TERM with id GO:0010455 * Created object of type obo:TERM with id GO:0031445 * Created object of type obo:TERM with id GO:0031452 * Created object of type obo:TERM with id GO:0031453 * Created object of type obo:TERM with id GO:0031454 * Created object of type obo:TERM with id GO:0033696 * Created object of type obo:TERM with id GO:0033697 * Created object of type obo:TERM with id GO:0033698 * Created object of type obo:TERM with id GO:0033699 * Populated new object GO:0010453 (macro) * Changed name of GO:0010453 from "" to "regulation of cell fate commitment" * Set definition of GO:0010453 to "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." * Added definition dbxref GOC:dph to GO:0010453 * Added definition dbxref GOC:tb to GO:0010453 * Copied GO:0010453 to GO:0045165 with type part_of * Copied GO:0010453 to GO:0045595 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0010453 * Populated new object GO:0010454 (macro) * Changed name of GO:0010454 from "" to "negative regulation of cell fate commitment" * Set definition of GO:0010454 to "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." * Added definition dbxref GOC:dph to GO:0010454 * Added definition dbxref GOC:tb to GO:0010454 * Copied GO:0010454 to GO:0045596 with type OBO_REL:is_a * Copied GO:0010454 to GO:0010453 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0010454 * Populated new object GO:0010455 (macro) * Changed name of GO:0010455 from "" to "positive regulation of cell fate commitment" * Set definition of GO:0010455 to "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." * Added definition dbxref GOC:dph to GO:0010455 * Added definition dbxref GOC:tb to GO:0010455 * Copied GO:0010455 to GO:0045597 with type OBO_REL:is_a * Copied GO:0010455 to GO:0010453 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0010455 * Populated new object GO:0031445 (macro) * Changed name of GO:0031445 from "" to "regulation of heterochromatin formation" * Set definition of GO:0031445 to "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." * Added definition dbxref GOC:mah to GO:0031445 * Copied GO:0031445 to GO:0031507 with type part_of * Copied GO:0031445 to GO:0033044 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0031445 * Populated new object GO:0031452 (macro) * Changed name of GO:0031452 from "" to "negative regulation of heterochromatin formation" * Set definition of GO:0031452 to "Any process that stops, prevents or reduces the frequency, rate or extent of heterochromatin formation." * Added definition dbxref GOC:mah to GO:0031452 * Added synonym "down regulation of heterochromatin formation" to GO:0031452 * Changed synonym scope of GO:0031452 from "Related" to "Exact" * Added synonym "down-regulation of heterochromatin formation" to GO:0031452 * Changed synonym scope of GO:0031452 from "Related" to "Exact" * Added synonym "downregulation of heterochromatin formation" to GO:0031452 * Changed synonym scope of GO:0031452 from "Related" to "Exact" * Added synonym "inhibition of heterochromatin formation" to GO:0031452 * Changed synonym scope of GO:0031452 from "Related" to "Narrow" * Copied GO:0031452 to GO:0031445 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0031452 * Populated new object GO:0031453 (macro) * Changed name of GO:0031453 from "" to "positive regulation of heterochromatin formation" * Set definition of GO:0031453 to "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." * Added definition dbxref GOC:mah to GO:0031453 * Added synonym "activation of heterochromatin formation" to GO:0031453 * Changed synonym scope of GO:0031453 from "Related" to "Narrow" * Added synonym "stimulation of heterochromatin formation" to GO:0031453 * Changed synonym scope of GO:0031453 from "Related" to "Narrow" * Added synonym "up regulation of heterochromatin formation" to GO:0031453 * Changed synonym scope of GO:0031453 from "Related" to "Exact" * Added synonym "up-regulation of heterochromatin formation" to GO:0031453 * Changed synonym scope of GO:0031453 from "Related" to "Exact" * Added synonym "upregulation of heterochromatin formation" to GO:0031453 * Changed synonym scope of GO:0031453 from "Related" to "Exact" * Copied GO:0031453 to GO:0031445 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0031453 * Populated new object GO:0031454 (macro) * Changed name of GO:0031454 from "" to "regulation of extent of heterochromatin formation" * Set definition of GO:0031454 to "Any process that modulates the extent or location of heterochromatin formation." * Added definition dbxref GOC:mah to GO:0031454 * Added synonym "regulation of heterochromatin spreading" to GO:0031454 * Copied GO:0031454 to GO:0031445 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0031454 * Populated new object GO:0033696 (macro) * Changed name of GO:0033696 from "" to "negative regulation of extent of heterochromatin formation" * Set definition of GO:0033696 to "Any process that reduces the extent of heterochromatin formation; reduces the size of a chromosomal region converted to heterochromatin." * Added definition dbxref GOC:mah to GO:0033696 * Added synonym "maintenance of heterochromatin boundaries" to GO:0033696 * Added synonym "negative regulation of heterochromatin spreading" to GO:0033696 * Copied GO:0033696 to GO:0031454 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0033696 * Populated new object GO:0033697 (macro) * Changed name of GO:0033697 from "" to "positive regulation of extent of heterochromatin formation" * Set definition of GO:0033697 to "Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." * Added definition dbxref GOC:mah to GO:0033697 * Added synonym "positive regulation of heterochromatin spreading" to GO:0033697 * Copied GO:0033697 to GO:0031454 with type OBO_REL:is_a * Assigned namespace "biological_process" to GO:0033697 * Populated new object GO:0033698 (macro) * Changed name of GO:0033698 from "" to "Clr6 histone deacetylase complex I/I'" * Set definition of GO:0033698 to "A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe)." * Added definition dbxref GOC:vw to GO:0033698 * Added definition dbxref PMID:17450151 to GO:0033698 * Copied GO:0033698 to GO:0000118 with type OBO_REL:is_a * Assigned namespace "cellular_component" to GO:0033698 * Populated new object GO:0033699 (macro) * Changed name of GO:0033699 from "" to "DNA 5'-adenosine monophosphate hydrolase activity" * Set definition of GO:0033699 to "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." * Added definition dbxref GOC:mah to GO:0033699 * Added definition dbxref PMID:16547001 to GO:0033699 * Added definition dbxref PMID:17276982 to GO:0033699 * Added synonym "AMP-removal activity" to GO:0033699 * Added synonym "DNA 5'-adenylate hydrolase activity" to GO:0033699 * Changed synonym scope of GO:0033699 from "Related" to "Exact" * Added synonym "DNA adenylate hydrolysis activity" to GO:0033699 * Changed synonym scope of GO:0033699 from "Related" to "Broad" * Added synonym "DNA de-adenylation" to GO:0033699 * Added synonym "DNA deadenylation" to GO:0033699 * Copied GO:0033699 to GO:0035312 with type OBO_REL:is_a * Assigned namespace "molecular_function" to GO:0033699 * Changed comment from "This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. To update annotations, consider biological_process term 'ribosome biogenesis and assembly ; GO:0042254' or its children and molecular_function term 'unfolded protein binding ; GO:0051082'." to "This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function." * Changed comment from "This term was made obsolete because it represents gene products. To update annotations, consider molecular_function term 'thiol-disulfide exchange intermediate activity ; GO:0030508'." to "This term was made obsolete because it represents gene products." * Changed comment from "This term was made obsolete because it describes a substrate-specific process. To update annotations, consider biological_process term 'negative regulation of mitotic recombination ; GO:0045950'." to "This term was made obsolete because it describes a substrate-specific process." * Changed comment from "This term was made obsolete because it describes a gene product and it contains component information. To update annotations, consider cellular_component term 'plasma membrane ; GO:0005886' or its children and molecular_function term 'long-chain fatty acid transporter activity ; GO:0005324' or its children." to "This term was made obsolete because it describes a gene product and it contains component information." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider molecular_function term 'electron carrier activity ; GO:0009055' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful concept. To update annotations, consider biological_process terms 'chromosome organization and biogenesis ; GO:0051276' or its children, 'chromosome segregation ; GO:0007059' or its children, and 'DNA replication ; GO:0006260' or its children." to "This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful concept." * Changed comment from "This term was made obsolete because it was not defined and the string name implied two separate processes. To update annotations, consider biological_process terms 'barrier septum formation ; GO:0000917' or its children, 'selection of site for barrier septum formation ; GO:0000918', and 'septin ring assembly ; GO:0000921'." to "This term was made obsolete because it was not defined and the string name implied two separate processes." * Changed comment from "This term was made obsolete because it is a gene product specific term. To update annotations, use biological_process term 'pheromone-dependent signal transduction during conjugation with cellular fusion ; GO:0000750'." to "This term was made obsolete because it is a gene product specific term." * Changed comment from "This term was made obsolete because more specific children exist. To update annotations, consider cellular_component terms 'cytosolic large ribosomal subunit (sensu Bacteria) ; GO:0009282' and 'cytosolic large ribosomal subunit (sensu Eukaryota) ; GO:0005842'." to "This term was made obsolete because more specific children exist." * Changed comment from "This term was made obsolete because more specific children exist. To update annotations, consider cellular_component terms 'cytosolic small ribosomal subunit (sensu Bacteria) ; GO:0009283' and 'cytosolic small ribosomal subunit (sensu Eukaryota) ; GO:0005843'." to "This term was made obsolete because more specific children exist." * Changed comment from "This term was made obsolete because it represents a biological process and a molecular function. To update annotations, consider biological_process terms 'modification-dependent protein catabolic process ; GO:0019941' or its children and 'protein ubiquitination during ubiquitin-dependent protein catabolic process ; GO:0042787' and molecular_function term 'protein binding ; GO:0005515' or its children." to "This term was made obsolete because it represents a biological process and a molecular function." * Changed comment from "This term was made obsolete because more specific terms were created. To update annotations, consider cellular_component term 'proton-transporting two-sector ATPase complex ; GO:0016469' or its children." to "This term was made obsolete because more specific terms were created." * Changed comment from "This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'condensed nuclear chromosome ; GO:0000794' or its children." to "This term was made obsolete because it is based on a temporal division of the cell cycle." * Changed comment from "This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'condensed chromosome ; GO:0000793' or its children." to "This term was made obsolete because it is based on a temporal division of the cell cycle." * Changed comment from "This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'nuclear chromosome ; GO:0000228' or its children." to "This term was made obsolete because it is based on a temporal division of the cell cycle." * Changed comment from "This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'cytoplasmic chromosome ; GO:0000229' or its children." to "This term was made obsolete because it is based on a temporal division of the cell cycle." * Changed comment from "This term was made obsolete because it represents a multifunctional gene product. To update annotations, consider molecular_function terms 'L-isoleucine transmembrane transporter activity ; GO:0015188', 'L-valine transmembrane transporter activity ; GO:0005304', and 'sodium:amino acid symporter activity ; GO:0005283' or its children." to "This term was made obsolete because it represents a multifunctional gene product." * Changed comment from "This term was made obsolete because it contains component and function information. To update annotations, use cellular_component term 'intracellular ; GO:0005622' and molecular_function term 'nucleoside transmembrane transporter activity ; GO:0005337'." to "This term was made obsolete because it contains component and function information." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'sodium-transporting ATPase activity, rotational mechanism ; GO:0046962'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, consider cellular_component term 'heterotrimeric G-protein complex ; GO:0005834' and molecular_function term 'GTPase activity ; GO:0003924'." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, consider cellular_component term 'heterotrimeric G-protein complex ; GO:0005834' and molecular_function term 'GTPase activity ; GO:0003924'." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, consider cellular_component term 'heterotrimeric G-protein complex ; GO:0005834' and molecular_function term 'GTPase activity ; GO:0003924'." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. To update annotations, use biological_process term 'cellular morphogenesis during conjugation with cellular fusion ; GO:0000753'." to "This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable." * Changed comment from "This term was made obsolete because more appropriate terms were created. To update annotations, consider biological_process terms 'entry into host ; GO:0044409' or its children and 'growth or development of symbiont within host ; GO:0044412' or its children." to "This term was made obsolete because more appropriate terms were created." * Changed comment from "This term was made obsolete because it is an amalgamation of its two children. To update annotations, consider biological_process terms 'neurotransmitter biosynthetic process ; GO:0042136' or its children and 'sequestering of neurotransmitter ; GO:0042137'." to "This term was made obsolete because it is an amalgamation of its two children." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider cellular_component term 'microfibril ; GO:0001527' or its children and molecular_function term 'calcium ion binding ; GO:0005509'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'oxygen transporter activity ; GO:0005344'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a group of molecular functions. To update annotations, consider biological_process terms 'proteoglycan metabolic process ; GO:0006029' or its children and 'sulfur metabolic process ; GO:0006790' or its children and molecular_function term 'proteoglycan sulfotransferase activity ; GO:0050698'." to "This term was made obsolete because it represents a group of molecular functions." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'extracellular matrix constituent conferring elasticity ; GO:0030023'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'extracellular matrix constituent conferring elasticity ; GO:0030023'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it is redundant with other terms; obsoleted as part of the metabolism rearrangements. To update annotations, use biological_process terms 'cell growth ; GO:0016049' and 'metabolic process ; GO:0008152'." to "This term was made obsolete because it is redundant with other terms; obsoleted as part of the metabolism rearrangements." * Changed comment from "This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. To update annotations, use biological_process term 'response to protozoan ; GO:0001562'." to "This term was made obsolete because 'resistance' implies a phenotype rather than a biological process." * Changed comment from "This term was made obsolete because it refers to a class of gene products. To update annotations, consider biological_process term 'heterophilic cell adhesion ; GO:0007157' or its children and molecular_function term 'galactoside binding ; GO:0016936'." to "This term was made obsolete because it refers to a class of gene products." * Changed comment from "This term was made obsolete because the function it represents does not exist. To update annotations, consider molecular_function term 'apelin receptor binding ; GO:0031704'." to "This term was made obsolete because the function it represents does not exist." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'axonemal dynein complex ; GO:0005858'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'axonemal dynein complex ; GO:0005858'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'axonemal dynein complex ; GO:0005858'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'axonemal dynein complex ; GO:0005858'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'cytoplasmic dynein complex ; GO:0005868'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'cytoplasmic dynein complex ; GO:0005868'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'cytoplasmic dynein complex ; GO:0005868'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'cytoplasmic dynein complex ; GO:0005868'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'intermediate filament ; GO:0005882'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'intermediate filament ; GO:0005882'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'intermediate filament ; GO:0005882'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'type III intermediate filament ; GO:0045098'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins. To update annotations, consider biological_process term 'compound eye photoreceptor development ; GO:0042051' or its children." to "This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins." * Deleted GO:0001981 --OBO_REL:is_a--> GO:0003018 * Copied GO:0001981 to GO:0003018 with type part_of * Deleted GO:0003078 --OBO_REL:is_a--> GO:0030147 * Copied GO:0003078 to GO:0030147 with type part_of * Changed comment from "This term was made obsolete because it represents two functions. To update annotations, use molecular_function terms 'chromatin binding ; GO:0003682' and 'lamin binding ; GO:0005521'." to "This term was made obsolete because it represents two functions." * Changed comment from "This term was made obsolete because it includes a process term. To update annotations, consider molecular_function term 'damaged DNA binding ; GO:0003684' or its children." to "This term was made obsolete because it includes a process term." * Changed comment from "This term was made obsolete because it includes a process term. To update annotations, consider molecular_function term 'damaged DNA binding ; GO:0003684' or its children." to "This term was made obsolete because it includes a process term." * Changed comment from "This term was made obsolete because it does not represent a true molecular function. To update annotations, consider biological_process term 'DNA replication ; GO:0006260' or its children." to "This term was made obsolete because it does not represent a true molecular function." * Changed comment from "This term was made obsolete because it refers to component information. To update annotations, consider cellular_component term 'extrachromosomal circular DNA ; GO:0005727' or its children and molecular_function term 'DNA binding ; GO:0003677' or its children." to "This term was made obsolete because it refers to component information." * Changed comment from "This term was made obsolete because sequestering is a process rather than a function. To update annotations, use biological_process term 'cytoplasmic sequestering of transcription factor ; GO:0042994'." to "This term was made obsolete because sequestering is a process rather than a function." * Changed comment from "This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. To update annotations, consider molecular_function term 'RNA cap binding ; GO:0000339' or its children." to "This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to." * Changed comment from "This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. To update annotations, consider molecular_function term 'RNA cap binding ; GO:0000339' or its children." to "This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to." * Changed comment from "This term was made obsolete because it describes a cellular component rather than a molecular function. To update annotations, use cellular_component term 'ribonucleoprotein complex ; GO:0030529'." to "This term was made obsolete because it describes a cellular component rather than a molecular function." * Changed comment from "This term was made obsolete because it describes a cellular component rather than a molecular function. To update annotations, use cellular_component term 'small nuclear ribonucleoprotein complex ; GO:0030532'." to "This term was made obsolete because it describes a cellular component rather than a molecular function." * Changed comment from "This term was made obsolete because it does not represent a single molecular function. To update annotations, use biological_process term 'regulation of progression through cell cycle ; GO:0000074'." to "This term was made obsolete because it does not represent a single molecular function." * Changed comment from "This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. To update annotations, consider biological_process term 'protein folding ; GO:0006457' or its children and molecular_function term 'unfolded protein binding ; GO:0051082'." to "This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes." * Changed comment from "This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. To update annotations, consider biological_process term 'protein folding ; GO:0006457' or its children and molecular_function term 'unfolded protein binding ; GO:0051082'." to "This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function." * Changed comment from "This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. To update annotations, consider biological_process terms 'chromatin assembly or disassembly ; GO:0006333' or its children and 'nucleosome assembly ; GO:0006334' or its children and molecular_function terms 'histone binding ; GO:0042393' or its children and 'unfolded protein binding ; GO:0051082'." to "This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function." * Changed comment from "This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. To update annotations, use molecular_function term 'ATPase activity, coupled ; GO:0042623' and consider biological_process term 'protein folding ; GO:0006457' or its children." to "This term was made obsolete because it represents a class of gene products, and its definition incorporates process information." * Changed comment from "This term was made obsolete because it represents a class of gene products rather than a molecular function. To update annotations, consider biological_process term 'protein folding ; GO:0006457' or its children and molecular_function term 'chaperone binding ; GO:0051087'." to "This term was made obsolete because it represents a class of gene products rather than a molecular function." * Changed comment from "This term was made obsolete because it represents a class of gene products rather than a molecular function. To update annotations, consider biological_process term 'protein folding ; GO:0006457' or its children and molecular_function term 'chaperone binding ; GO:0051087'." to "This term was made obsolete because it represents a class of gene products rather than a molecular function." * Changed comment from "This term was made obsolete because it represents a class of gene products rather than a molecular function. To update annotations, consider biological_process terms 'protein refolding ; GO:0042026' and 'response to unfolded protein ; GO:0006986' or its children." to "This term was made obsolete because it represents a class of gene products rather than a molecular function." * Changed comment from "This term was made obsolete because it includes cellular component information. To update annotations, consider cellular_component term 'axoneme ; GO:0005930' or its children and molecular_function term 'microtubule motor activity ; GO:0003777' or its children." to "This term was made obsolete because it includes cellular component information." * Changed comment from "This term was made obsolete because it includes anatomy information. To update annotations, use molecular_function term 'microfilament motor activity ; GO:0000146' and consider biological_process term 'muscle contraction ; GO:0006936' or its children and cellular_component term 'contractile fiber ; GO:0043292' or its children." to "This term was made obsolete because it includes anatomy information." * Changed comment from "This term was made obsolete because it represents a combination of molecular functions. To update annotations, use molecular_function terms 'actin filament binding ; GO:0051015' and 'protein binding, bridging ; GO:0030674'." to "This term was made obsolete because it represents a combination of molecular functions." * Changed comment from "This term was made obsolete because it represents a biological process. To update annotations, use biological_process term 'actin filament bundle formation ; GO:0051017'." to "This term was made obsolete because it represents a biological process." * Changed comment from "This term was made obsolete because it describes a biological process. To update annotations, use biological_process term 'barbed-end actin filament capping ; GO:0051016'." to "This term was made obsolete because it describes a biological process." * Changed comment from "This term was made obsolete because it describes a biological process. To update annotations, use biological_process term 'barbed-end actin filament capping ; GO:0051016'." to "This term was made obsolete because it describes a biological process." * Changed comment from "This term was made obsolete because it describes two biological processes. To update annotations, use biological_process terms 'actin filament severing ; GO:0051014' and 'barbed-end actin filament capping ; GO:0051016'." to "This term was made obsolete because it describes two biological processes." * Changed comment from "This term was made obsolete because it represents a biological process. To update annotations, use biological_process term 'actin filament depolymerization ; GO:0030042'." to "This term was made obsolete because it represents a biological process." * Changed comment from "This term was made obsolete because sequestering is a process, not an activity. To update annotations, use biological_process term 'sequestering of actin monomers ; GO:0042989'." to "This term was made obsolete because sequestering is a process, not an activity." * Changed comment from "This term was made obsolete because it describes a biological process. To update annotations, use biological_process term 'actin filament severing ; GO:0051014'." to "This term was made obsolete because it describes a biological process." * Changed comment from "This term was made obsolete because it does not make sense. To update annotations, consider biological_process term 'actin cytoskeleton organization and biogenesis ; GO:0030036' or its children." to "This term was made obsolete because it does not make sense." * Changed comment from "This term was made obsolete because it contains both component and function information. To update annotations, consider cellular_component term 'membrane ; GO:0016020' or its children and molecular_function term 'actin binding ; GO:0003779' or its children." to "This term was made obsolete because it contains both component and function information." * Changed comment from "This term was made obsolete because the concept belongs in the process ontology. To update annotations, use biological_process term 'regulation of actin filament length ; GO:0030832'." to "This term was made obsolete because the concept belongs in the process ontology." * Changed comment from "This term was made obsolete because it refers to involvement in a biological process. To update annotations, consider biological_process term 'defense response ; GO:0006952' or its children." to "This term was made obsolete because it refers to involvement in a biological process." * Changed comment from "This term was made obsolete because it refers to involvement in a biological process. To update annotations, consider biological_process term 'acute-phase response ; GO:0006953' or its children." to "This term was made obsolete because it refers to involvement in a biological process." * Changed comment from "This term was made obsolete because it describes involvement in a process and not a function. To update annotations, consider biological_process term 'defense response ; GO:0006952' or its children." to "This term was made obsolete because it describes involvement in a process and not a function." * Changed comment from "This term was made obsolete because it describes involvement in a process and not a function. To update annotations, consider biological_process term 'defense response to bacterium ; GO:0042742' or its children." to "This term was made obsolete because it describes involvement in a process and not a function." * Changed comment from "This term was made obsolete because it describes involvement in a process and not a function. To update annotations, consider biological_process term 'male-specific defense response to bacterium ; GO:0050831' or its children." to "This term was made obsolete because it describes involvement in a process and not a function." * Changed comment from "This term was made obsolete because it describes involvement in a process and not a function. To update annotations, consider biological_process term 'defense response to fungus ; GO:0050832' or its children." to "This term was made obsolete because it describes involvement in a process and not a function." * Changed comment from "This term was made obsolete because it refers to involvement in a biological process. To update annotations, consider biological_process term 'response to virus ; GO:0009615' or its children." to "This term was made obsolete because it refers to involvement in a biological process." * Changed comment from "This term was made obsolete because it refers to involvement in a biological process. To update annotations, consider biological_process term 'blood coagulation ; GO:0007596' or its children and molecular_function term 'serine-type endopeptidase activity ; GO:0004252' or its children." to "This term was made obsolete because it refers to involvement in a biological process." * Changed comment from "This term was made obsolete because it refers to involvement in a biological process. To update annotations, consider biological_process term 'complement activation ; GO:0006956' or its children." to "This term was made obsolete because it refers to involvement in a biological process." * Changed comment from "This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. To update annotations, consider cellular_component term 'MHC class I protein complex ; GO:0042612'." to "This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity." * Changed comment from "This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. To update annotations, consider cellular_component term 'MHC class II protein complex ; GO:0042613'." to "This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity." * Changed comment from "This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. To update annotations, use molecular_function term 'DNA-directed RNA polymerase activity ; GO:0003899'." to "This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'." * Changed comment from "This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. To update annotations, use molecular_function term 'DNA-directed RNA polymerase activity ; GO:0003899'." to "This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'." * Changed comment from "This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'. To update annotations, use molecular_function term 'DNA-directed RNA polymerase activity ; GO:0003899'." to "This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'." * Changed comment from "This term was made obsolete because it represents a gene product and contains cellular component information. To update annotations, use molecular_function term 'GTPase activity ; GO:0003924'." to "This term was made obsolete because it represents a gene product and contains cellular component information." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'GTPase activity ; GO:0003924' and consider biological_process terms 'synaptic vesicle uncoating ; GO:0016191' and 'vesicle-mediated transport ; GO:0016192' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a cellular component. To update annotations, use cellular_component term 'heterotrimeric G-protein complex ; GO:0005834' and molecular_function term 'GTPase activity ; GO:0003924'." to "This term was made obsolete because it represents a cellular component." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'GTPase activity ; GO:0003924' and consider biological_process terms 'synaptic vesicle uncoating ; GO:0016191' and 'vesicle-mediated transport ; GO:0016192' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'GTPase activity ; GO:0003924' and consider biological_process term 'protein import into nucleus ; GO:0006606' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'GTPase activity ; GO:0003924' and consider biological_process term 'regulation of cell growth ; GO:0001558' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'GTPase activity ; GO:0003924' and consider biological_process term 'cytoskeleton organization and biogenesis ; GO:0007010' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'GTPase activity ; GO:0003924' and consider biological_process term 'secretion ; GO:0046903' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it refers to a bifunctional gene product. To update annotations, consider molecular_function terms 'hydrogen ion transporting ATP synthase activity, rotational mechanism ; GO:0046933' and 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'." to "This term was made obsolete because it refers to a bifunctional gene product." * Changed comment from "This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. To update annotations, use molecular_function term 'RNA-directed DNA polymerase activity ; GO:0003964'." to "This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'." * Changed comment from "This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. To update annotations, use molecular_function term 'RNA-directed DNA polymerase activity ; GO:0003964'." to "This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'." * Changed comment from "This term was made obsolete because it contains both component and function information. To update annotations, consider cellular_component term 'plasma membrane ; GO:0005886' or its children and molecular_function term 'cation-transporting ATPase activity ; GO:0019829' or its children." to "This term was made obsolete because it contains both component and function information." * Changed comment from "This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). To update annotations, consider molecular_function term 'metal ion transmembrane transporter activity ; GO:0046873' or its children." to "This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information)." * Changed comment from "This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. To update annotations, consider cellular_component term 'ATP-binding cassette (ABC) transporter complex ; GO:0043190' or its children and molecular_function term 'ATPase activity, coupled to transmembrane movement of substances ; GO:0042626' or its children." to "This term was made obsolete because ABC transporters are a protein family rather than a functional grouping." * Changed comment from "This term was made obsolete because it represents a gene product which can catalyze two reactions. To update annotations, consider molecular_function terms 'nucleoside-diphosphatase activity ; GO:0017110' or its children and 'nucleoside-triphosphatase activity ; GO:0017111' or its children." to "This term was made obsolete because it represents a gene product which can catalyze two reactions." * Changed comment from "This term was made obsolete because it represents a multistep reaction. To update annotations, use biological_process term 'spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase ; GO:0050983'." to "This term was made obsolete because it represents a multistep reaction." * Changed comment from "This term was made obsolete because it represents two molecular functions. To update annotations, consider molecular_function terms 'ecdysteroid UDP-glucosyltransferase activity ; GO:0050488' and 'ecdysteroid UDP-glucuronosyltransferase activity ; GO:0050489'." to "This term was made obsolete because it represents two molecular functions." * Changed comment from "This term was made obsolete because it includes biological process information. To update annotations, use molecular_function term 'caspase activity ; GO:0030693' and consider biological_process term 'apoptosis ; GO:0006915' or its children." to "This term was made obsolete because it includes biological process information." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it includes biological process information. To update annotations, use molecular_function term 'caspase activity ; GO:0030693' and consider biological_process term 'apoptosis ; GO:0006915' or its children." to "This term was made obsolete because it includes biological process information." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'caspase activity ; GO:0030693'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it contains both component and function information. To update annotations, consider cellular_component term 'lysosome ; GO:0005764' or its children and molecular_function term 'cysteine-type endopeptidase activity ; GO:0004197' or its children." to "This term was made obsolete because it contains both component and function information." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider cellular_component term 'mitochondrion ; GO:0005739' or its children and molecular_function term 'mitochondrial processing peptidase activity ; GO:0004240'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider cellular_component term 'mitochondrion ; GO:0005739' or its children and molecular_function term 'mitochondrial processing peptidase activity ; GO:0004240'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it contains both component and function information. To update annotations, consider cellular_component term 'vacuole ; GO:0005773' or its children and molecular_function term 'carboxypeptidase C activity ; GO:0004186'." to "This term was made obsolete because it contains both component and function information." * Changed comment from "This term was made obsolete because it mentions a component term in the text string. To update annotations, consider molecular_function terms 'endopeptidase activity ; GO:0004175' or its children and 'peptidase activity ; GO:0008233' or its children." to "This term was made obsolete because it mentions a component term in the text string." * Changed comment from "This term was made obsolete because it represents a multifunctional gene product. To update annotations, consider molecular_function terms 'ferroxidase activity ; GO:0004322' and 'iron ion transmembrane transporter activity ; GO:0005381' or its children." to "This term was made obsolete because it represents a multifunctional gene product." * Changed comment from "This term was made obsolete because it represents a process rather than a function. To update annotations, use biological_process term 'glycine decarboxylation via glycine cleavage system ; GO:0019464'." to "This term was made obsolete because it represents a process rather than a function." * Changed comment from "This term was made obsolete because it represents a gene product and not a function. To update annotations, consider biological_process term 'cell adhesion ; GO:0007155' or its children, cellular_component term 'integral to membrane ; GO:0016021' or its children, and molecular_function terms 'cell adhesion molecule binding ; GO:0050839' or its children, 'guanylate kinase activity ; GO:0004385', and 'receptor binding ; GO:0005102' or its children." to "This term was made obsolete because it represents a gene product and not a function." * Changed comment from "This term was made obsolete because it is not a valid molecular function. To update annotations, consider molecular_function term '1-phosphatidylinositol-4-phosphate 5-kinase activity ; GO:0016308'." to "This term was made obsolete because it is not a valid molecular function." * Changed comment from "This term was made obsolete because it is not a valid molecular function. To update annotations, consider molecular_function term '1-phosphatidylinositol-4-phosphate 5-kinase activity ; GO:0016308'." to "This term was made obsolete because it is not a valid molecular function." * Removed comment * Removed comment * Changed comment from "This term was made obsolete because the existence of this function has not been established. To update annotations, consider molecular_function term 'inositol trisphosphate phosphatase activity ; GO:0046030' or its children." to "This term was made obsolete because the existence of this function has not been established." * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, consider molecular_function terms 'cyclosporin A binding ; GO:0016018' and 'peptidyl-prolyl cis-trans isomerase activity ; GO:0003755' or its children." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it represents component and function information. To update annotations, use cellular_component term 'extracellular region ; GO:0005576' and molecular_function term 'phospholipase A2 activity ; GO:0004623'." to "This term was made obsolete because it represents component and function information." * Changed comment from "This term was made obsolete because it represents component and function information. To update annotations, use cellular_component term 'extracellular region ; GO:0005576' and molecular_function term 'calcium-dependent phospholipase A2 activity ; GO:0047498'." to "This term was made obsolete because it represents component and function information." * Changed comment from "This term was made obsolete because it represents component and function information. To update annotations, use cellular_component term 'cytosol ; GO:0005829' and molecular_function term 'phospholipase A2 activity ; GO:0004623'." to "This term was made obsolete because it represents component and function information." * Changed comment from "This term was made obsolete because it represents component and function information. To update annotations, use cellular_component term 'cytosol ; GO:0005829' and molecular_function term 'calcium-dependent phospholipase A2 activity ; GO:0047498'." to "This term was made obsolete because it represents component and function information." * Changed comment from "This term was made obsolete because it represents component and function information. To update annotations, use cellular_component term 'cytosol ; GO:0005829' and molecular_function term 'calcium-independent phospholipase A2 activity ; GO:0047499'." to "This term was made obsolete because it represents component and function information." * Changed comment from "This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function. To update annotations, use molecular_function term 'protein-tyrosine kinase activity ; GO:0004713'." to "This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function." * Changed comment from "This term was made obsolete because the function is covered by an existing term. To update annotations, consider molecular_function term 'superoxide dismutase activity ; GO:0004784' or its children." to "This term was made obsolete because the function is covered by an existing term." * Changed comment from "This term was made obsolete because it represents a class of gene products. To update annotations, consider molecular_function term 'serine-type endopeptidase inhibitor activity ; GO:0004867' or its children." to "This term was made obsolete because it represents a class of gene products." * Changed comment from "This term was made obsolete because it describes the receptor type, and not an activity. To update annotations, consider molecular_function term 'antigen binding ; GO:0003823' or its children." to "This term was made obsolete because it describes the receptor type, and not an activity." * Changed comment from "This term was made obsolete because it describes a receptor type, and not an activity. To update annotations, consider molecular_function terms 'MHC class Ib receptor activity ; GO:0032394', 'MHC class II receptor activity ; GO:0032395', and 'peptide antigen binding ; GO:0042605' or its children." to "This term was made obsolete because it describes a receptor type, and not an activity." * Changed comment from "This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. To update annotations, consider biological_process term 'cell adhesion ; GO:0007155' or its children, cellular_component term 'integral to membrane ; GO:0016021' or its children, and molecular_function terms 'carbohydrate binding ; GO:0030246' or its children, 'cell adhesion molecule binding ; GO:0050839' or its children, 'protein binding ; GO:0005515' or its children, and 'receptor binding ; GO:0005102' or its children." to "This term was made obsolete because it represents gene products involved in the biological process of cell adhesion." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider molecular_function terms 'ciliary neurotrophic factor receptor activity ; GO:0004897' or its children, 'hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity ; GO:0005062' or its children, 'interleukin-11 receptor activity ; GO:0004921', and 'interleukin-6 receptor activity ; GO:0004915'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product rather than an activity. To update annotations, consider molecular_function terms 'boss receptor activity ; GO:0008288', 'non-G-protein coupled 7TM receptor activity ; GO:0004926', and 'transmembrane receptor protein tyrosine kinase activity ; GO:0004714' or its children." to "This term was made obsolete because it represents a gene product rather than an activity." * Changed comment from "This term was made obsolete because it represents a gene product rather than an activity. To update annotations, use molecular_function term 'Wnt receptor activity ; GO:0042813' and consider biological_process term 'Wnt receptor signaling pathway ; GO:0016055' or its children." to "This term was made obsolete because it represents a gene product rather than an activity." * Changed comment from "This term was made obsolete because it represents a gene product rather than an activity. To update annotations, use molecular_function term 'Wnt receptor activity ; GO:0042813' and consider biological_process term 'Wnt receptor signaling pathway, calcium modulating pathway ; GO:0007223' or its children." to "This term was made obsolete because it represents a gene product rather than an activity." * Changed comment from "This term was made obsolete because it represents a gene product and not a molecular function. To update annotations, consider molecular_function terms 'protein binding ; GO:0005515' or its children and 'receptor binding ; GO:0005102' or its children." to "This term was made obsolete because it represents a gene product and not a molecular function." * Changed comment from "This term was made obsolete because it represents a class of receptor rather than an activity. To update annotations, consider molecular_function term 'ErbB-3 class receptor binding ; GO:0043125'." to "This term was made obsolete because it represents a class of receptor rather than an activity." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider biological_process term 'signal transduction ; GO:0007165' or its children and molecular_function terms 'growth factor binding ; GO:0019838' or its children, 'neurotrophin binding ; GO:0043121' or its children, and 'transmembrane receptor protein tyrosine kinase activity ; GO:0004714' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider biological_process term 'signal transduction ; GO:0007165' or its children and molecular_function terms 'nerve growth factor binding ; GO:0048406', 'neurotrophin-3 binding ; GO:0048404', and 'transmembrane receptor protein tyrosine kinase activity ; GO:0004714' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider biological_process term 'signal transduction ; GO:0007165' or its children and molecular_function terms 'brain-derived neurotrophic factor binding ; GO:0048403', 'neurotrophin-3 binding ; GO:0048404', 'neurotrophin-4/5 binding ; GO:0048405', and 'transmembrane receptor protein tyrosine kinase activity ; GO:0004714' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider biological_process term 'signal transduction ; GO:0007165' or its children and molecular_function terms 'neurotrophin-3 binding ; GO:0048404' and 'transmembrane receptor protein tyrosine kinase activity ; GO:0004714' or its children." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a protein family rather than a molecular function. To update annotations, consider molecular_function term 'tumor necrosis factor receptor activity ; GO:0005031'." to "This term was made obsolete because it represents a protein family rather than a molecular function." * Changed comment from "This term was made obsolete because it describes the receptor type, and not an activity. To update annotations, consider molecular_function term 'CD154 receptor binding ; GO:0042615'." to "This term was made obsolete because it describes the receptor type, and not an activity." * Changed comment from "This term was made obsolete because it describes the receptor type, and not an activity. To update annotations, consider molecular_function term 'CD70 receptor binding ; GO:0042614'." to "This term was made obsolete because it describes the receptor type, and not an activity." * Changed comment from "This term was made obsolete because it represents a gene product and not a molecular function. To update annotations, consider molecular_function terms 'death receptor binding ; GO:0005123' and 'protein binding ; GO:0005515' or its children." to "This term was made obsolete because it represents a gene product and not a molecular function." * Changed comment from "This term was made obsolete because it represents a gene product and not a molecular function. To update annotations, consider molecular_function terms 'death receptor binding ; GO:0005123' and 'protein binding ; GO:0005515' or its children." to "This term was made obsolete because it represents a gene product and not a molecular function." * Changed comment from "This term was made obsolete because it represents a gene product and not a molecular function. To update annotations, consider molecular_function terms 'death receptor binding ; GO:0005123' and 'protein binding ; GO:0005515' or its children." to "This term was made obsolete because it represents a gene product and not a molecular function." * Changed comment from "This term was made obsolete because it represents cellular component and molecular function information. To update annotations, use cellular_component term 'endoplasmic reticulum ; GO:0005783' and molecular_function term 'receptor activity ; GO:0004872'." to "This term was made obsolete because it represents cellular component and molecular function information." * Changed comment from "This term was made obsolete because it describes a cellular component. To update annotations, consider cellular_component term 'peroxisome ; GO:0005777' or its children and molecular_function term 'receptor activity ; GO:0004872' or its children." to "This term was made obsolete because it describes a cellular component." * Changed comment from "This term was made obsolete because it describes a cellular component. To update annotations, consider cellular_component term 'peroxisomal membrane ; GO:0005778' or its children and molecular_function term 'receptor activity ; GO:0004872' or its children." to "This term was made obsolete because it describes a cellular component." * Changed comment from "This term was made obsolete because it represents a cellular component and not a molecular function. To update annotations, use cellular_component term 'heterotrimeric G-protein complex ; GO:0005834'." to "This term was made obsolete because it represents a cellular component and not a molecular function." * Changed comment from "This term was made obsolete because it names a family of gene products. To update annotations, use molecular_function term 'transforming growth factor beta receptor, common-partner cytoplasmic mediator activity ; GO:0030616'." to "This term was made obsolete because it names a family of gene products." * Changed comment from "This term was made obsolete because it names a family of gene products. To update annotations, use molecular_function term 'transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ; GO:0030617'." to "This term was made obsolete because it names a family of gene products." * Changed comment from "This term was made obsolete because it represents a family of gene products. To update annotations, use molecular_function term 'transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ; GO:0030618'." to "This term was made obsolete because it represents a family of gene products." * Changed comment from "This term was made obsolete because it represents a combination of process and function information. To update annotations, use biological_process term 'protein localization ; GO:0008104' and molecular_function term 'mitogen-activated protein kinase binding ; GO:0051019'." to "This term was made obsolete because it represents a combination of process and function information." * Changed comment from "This term was made obsolete because it represents a combination of process and function information. To update annotations, use biological_process term 'protein localization ; GO:0008104' and molecular_function term 'protein kinase A binding ; GO:0051018'." to "This term was made obsolete because it represents a combination of process and function information." * Changed comment from "This term was made obsolete because it refers to a class of gene products. To update annotations, consider molecular_function term 'ephrin receptor binding ; GO:0046875'." to "This term was made obsolete because it refers to a class of gene products." * Changed comment from "This term was made obsolete because it refers to a class of gene products. To update annotations, consider cellular_component term 'anchored to plasma membrane ; GO:0046658' or its children and molecular_function term 'ephrin receptor binding ; GO:0046875'." to "This term was made obsolete because it refers to a class of gene products." * Changed comment from "This term was made obsolete because it refers to a class of gene products. To update annotations, consider cellular_component term 'integral to plasma membrane ; GO:0005887' or its children and molecular_function term 'ephrin receptor binding ; GO:0046875'." to "This term was made obsolete because it refers to a class of gene products." * Removed comment * Changed comment from "This term was made obsolete because it describes a type of hormone rather than a molecular function. To update annotations, consider molecular_function term 'hormone activity ; GO:0005179' or its children." to "This term was made obsolete because it describes a type of hormone rather than a molecular function." * Changed comment from "This term was made obsolete because it describes a type of hormone rather than a molecular function. To update annotations, consider molecular_function term 'hormone activity ; GO:0005179' or its children." to "This term was made obsolete because it describes a type of hormone rather than a molecular function." * Changed comment from "This term was made obsolete because it describes a type of hormone rather than a molecular function. To update annotations, consider molecular_function term 'hormone activity ; GO:0005179' or its children." to "This term was made obsolete because it describes a type of hormone rather than a molecular function." * Changed comment from "This term was made obsolete because it describes a cellular location rather than a function. To update annotations, use molecular_function term 'nutrient reservoir activity ; GO:0045735'." to "This term was made obsolete because it describes a cellular location rather than a function." * Changed comment from "This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. To update annotations, consider biological_process term 'cell adhesion ; GO:0007155' or its children, cellular_component term 'integral to membrane ; GO:0016021' or its children, and molecular_function terms 'carbohydrate binding ; GO:0030246' or its children, 'cell adhesion molecule binding ; GO:0050839' or its children, 'protein binding ; GO:0005515' or its children, and 'receptor binding ; GO:0005102' or its children." to "This term was made obsolete because it represents gene products involved in the biological process of cell adhesion." * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, consider cellular_component term 'collagen ; GO:0005581' or its children." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it describes localization and modification rather than activity. To update annotations, consider molecular_function term 'extracellular matrix structural constituent ; GO:0005201' or its children." to "This term was made obsolete because it describes localization and modification rather than activity." * Changed comment from "This term was made obsolete because it does not describe a molecular function. To update annotations, consider molecular_function term 'protein binding ; GO:0005515' or its children." to "This term was made obsolete because it does not describe a molecular function." * Changed comment from "This term was made obsolete because more specific terms were created. To update annotations, consider molecular_function term 'inward rectifier potassium channel activity ; GO:0005242' or its children." to "This term was made obsolete because more specific terms were created." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'amino acid transmembrane transporter activity ; GO:0015171' and external ontology term 'amino acid permease activity ; GO:0015359'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a multifunctional gene product. To update annotations, consider molecular_function terms 'L-tryptophan transmembrane transporter activity ; GO:0015196' or its children, 'L-tyrosine transmembrane transporter activity ; GO:0005302', 'L-valine transmembrane transporter activity ; GO:0005304', and 'transmembrane transporter activity ; GO:0022857' or its children and external ontology term 'permease activity ; GO:0015646'." to "This term was made obsolete because it represents a multifunctional gene product." * Changed comment from "This term was made obsolete because it represents a multifunctional gene product. To update annotations, consider molecular_function terms 'dicarboxylic acid transmembrane transporter activity ; GO:0005310' or its children, 'organic acid:sodium symporter activity ; GO:0005343' or its children, and 'tricarboxylic acid transmembrane transporter activity ; GO:0015142' or its children." to "This term was made obsolete because it represents a multifunctional gene product." * Removed comment * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, consider molecular_function term 'lipid transporter activity ; GO:0005319' or its children." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, use molecular_function term 'lipid transporter activity ; GO:0005319'." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, use molecular_function term 'lipid transporter activity ; GO:0005319'." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it does not represent a molecular function. To update annotations, use molecular_function term 'lipid transporter activity ; GO:0005319'." to "This term was made obsolete because it does not represent a molecular function." * Changed comment from "This term was made obsolete because it represents a gene product and not a molecular function. To update annotations, consider molecular_function terms 'metal ion transmembrane transporter activity ; GO:0046873' or its children and 'secondary active transmembrane transporter activity ; GO:0015291' or its children." to "This term was made obsolete because it represents a gene product and not a molecular function." * Changed comment from "This term was made obsolete because it contains both component and function information. To update annotations, consider cellular_component term 'plasma membrane ; GO:0005886' or its children and molecular_function term 'copper ion transmembrane transporter activity ; GO:0005375' or its children." to "This term was made obsolete because it contains both component and function information." * Changed comment from "This term was made obsolete because it contains both component and function information. To update annotations, use cellular_component term 'intracellular ; GO:0005622' and molecular_function term 'copper ion transmembrane transporter activity ; GO:0005375'." to "This term was made obsolete because it contains both component and function information." * Changed comment from "This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong. To update annotations, consider biological_process term 'negative regulation of potassium ion transport ; GO:0043267'." to "This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong." * Changed comment from "This term was made obsolete because it contains both component and function information. To update annotations, consider cellular_component term 'peroxisome ; GO:0005777' or its children and molecular_function term 'transporter activity ; GO:0005215' or its children." to "This term was made obsolete because it contains both component and function information." * Changed comment from "This term was made obsolete because it does not provide a useful functional classification. To update annotations, consider molecular_function term 'transporter activity ; GO:0005215' or its children." to "This term was made obsolete because it does not provide a useful functional classification." * Changed comment from "This term was made obsolete because it represents a biological process and not a molecular function. To update annotations, use biological_process term 'vacuole organization and biogenesis ; GO:0007033'." to "This term was made obsolete because it represents a biological process and not a molecular function." * Changed comment from "This term was made obsolete because it represents a biological process and not a molecular function. To update annotations, use biological_process term 'vesicle-mediated transport ; GO:0016192'." to "This term was made obsolete because it represents a biological process and not a molecular function." * Changed comment from "This term was made obsolete because it represents a biological process and not a molecular function. To update annotations, consider biological_process terms 'synaptic vesicle to endosome fusion ; GO:0016189', 'vesicle fusion ; GO:0006906' or its children, 'vesicle fusion with nuclear membrane ; GO:0007086', 'vesicle fusion with peroxisome ; GO:0019817', and 'vesicle-mediated transport ; GO:0016192' or its children." to "This term was made obsolete because it represents a biological process and not a molecular function." * Changed comment from "This term was made obsolete because it represents a biological process and not a molecular function. To update annotations, consider biological_process term 'vesicle targeting ; GO:0006903' or its children and external ontology term 'synaptic vesicle targeting ; GO:GO:0016080'." to "This term was made obsolete because it represents a biological process and not a molecular function." * Changed comment from "This term was made obsolete because the activity described by the definition does not exist. To update annotations, use molecular_function term 'electron carrier activity ; GO:0009055'." to "This term was made obsolete because the activity described by the definition does not exist." * Changed comment from "This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). To update annotations, consider molecular_function term 'metal ion binding ; GO:0046872' or its children." to "This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information)." * Changed comment from "This term was made obsolete because it represents a composite function. To update annotations, consider molecular_function terms 'cadmium ion binding ; GO:0046870' and 'copper ion binding ; GO:0005507'." to "This term was made obsolete because it represents a composite function." * Changed comment from "This term was made obsolete because it represents a biological process. To update annotations, use biological_process term 'sequestering of calcium ion ; GO:0051208' and molecular_function term 'calcium ion binding ; GO:0005509'." to "This term was made obsolete because it represents a biological process." * Changed comment from "This term was made obsolete because it refers to a class of gene products. To update annotations, consider biological_process term 'heterophilic cell adhesion ; GO:0007157' or its children and molecular_function term 'sugar binding ; GO:0005529' or its children." to "This term was made obsolete because it refers to a class of gene products." * Changed comment from "This term was made obsolete because it refers to a class of gene products. To update annotations, consider biological_process term 'heterophilic cell adhesion ; GO:0007157' or its children and molecular_function term 'galactose binding ; GO:0005534'." to "This term was made obsolete because it refers to a class of gene products." * Changed comment from "This term was made obsolete because it refers to a class of gene products. To update annotations, consider biological_process term 'heterophilic cell adhesion ; GO:0007157' or its children and molecular_function term 'mannose binding ; GO:0005537'." to "This term was made obsolete because it refers to a class of gene products." * Changed comment from "This term was made obsolete because it refers to a class of gene products. To update annotations, consider biological_process term 'heterophilic cell adhesion ; GO:0007157' or its children and molecular_function term 'N-acetylgalactosamine binding ; GO:0046871'." to "This term was made obsolete because it refers to a class of gene products." * Changed comment from "This term was made obsolete because it was replaced by more appropriate terms. To update annotations, consider molecular_function terms 'acyl binding ; GO:0000035' and 'acyl-CoA binding ; GO:0000062'." to "This term was made obsolete because it was replaced by more appropriate terms." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider biological_process term 'protein ubiquitination ; GO:0016567' or its children and molecular_function term 'protein tag ; GO:0031386'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product and not a molecular function. To update annotations, consider biological_process term 'protein polyubiquitination ; GO:0000209'." to "This term was made obsolete because it represents a gene product and not a molecular function." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'triplet codon-amino acid adaptor activity ; GO:0030533'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, consider cellular_component term 'ribosome ; GO:0005840' or its children and molecular_function term 'structural constituent of ribosome ; GO:0003735'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents gene products. To update annotations, consider molecular_function term 'RNA modification guide activity ; GO:0030555' or its children." to "This term was made obsolete because it represents gene products." * Changed comment from "This term was made obsolete because it represents gene products. To update annotations, consider molecular_function terms 'RNA splicing factor activity, transesterification mechanism ; GO:0031202' or its children and 'snRNA binding ; GO:0017069' or its children." to "This term was made obsolete because it represents gene products." * Changed comment from "This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'template for synthesis of G-rich strand of telomere DNA activity ; GO:0000332'." to "This term was made obsolete because it represents a gene product." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'membrane attack complex ; GO:0005579'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family. To update annotations, consider cellular_component term 'integrin complex ; GO:0008305'." to "This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family." * Changed comment from "This term was made obsolete because it is a type of cell rather than a cellular component. To update annotations, consider external ontology term 'ascus ; FAO:0000014'." to "This term was made obsolete because it is a type of cell rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use molecular_function term 'Ran GTPase binding ; GO:0008536' and consider cellular_component terms 'cytoplasm ; GO:0005737' or its children, 'nuclear pore ; GO:0005643' or its children, and 'nucleus ; GO:0005634' or its children." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component terms 'cytoplasm ; GO:0005737' or its children, 'nuclear pore ; GO:0005643' or its children, and 'nucleus ; GO:0005634' or its children." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component terms 'cytoplasm ; GO:0005737' or its children, 'nuclear pore ; GO:0005643' or its children, and 'nucleus ; GO:0005634' or its children." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component terms 'cytoplasm ; GO:0005737' or its children, 'nuclear pore ; GO:0005643' or its children, and 'nucleus ; GO:0005634' or its children." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component terms 'cytoplasm ; GO:0005737' or its children, 'nuclear pore ; GO:0005643' or its children, and 'nucleus ; GO:0005634' or its children." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component terms 'cytoplasm ; GO:0005737' or its children, 'nuclear pore ; GO:0005643' or its children, and 'nucleus ; GO:0005634' or its children." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component terms 'cytoplasm ; GO:0005737' or its children, 'nuclear pore ; GO:0005643' or its children, and 'nucleus ; GO:0005634' or its children." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature. To update annotations, use cellular_component terms 'DNA replication factor C complex ; GO:0005663' and 'PCNA complex ; GO:0043626'." to "This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, use cellular_component term 'transcription factor TFIID complex ; GO:0005669'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. To update annotations, consider cellular_component terms 'chromosome ; GO:0005694' or its children, 'condensed chromosome ; GO:0000793' or its children, and 'condensed nuclear chromosome ; GO:0000794' or its children." to "This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions." * Changed comment from "This term was made obsolete because the definition was too sequence oriented and too restrictive. To update annotations, consider cellular_component terms 'chromosome, telomeric region ; GO:0000781' or its children and 'telomere cap complex ; GO:0000782' or its children." to "This term was made obsolete because the definition was too sequence oriented and too restrictive." * Changed comment from "This term was made obsolete because it is genetically defined region and not a specific subcellular localization. To update annotations, consider cellular_component term 'chromosome, pericentric region ; GO:0000775' or its children." to "This term was made obsolete because it is genetically defined region and not a specific subcellular localization." * Changed comment from "This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'chromosome ; GO:0005694' or its children." to "This term was made obsolete because it is based on a temporal division of the cell cycle." * Changed comment from "This term was made obsolete because it is based on a process. To update annotations, consider cellular_component terms 'condensed chromosome ; GO:0000793' or its children and 'condensed nuclear chromosome ; GO:0000794' or its children." to "This term was made obsolete because it is based on a process." * Changed comment from "This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'chromosome ; GO:0005694' or its children." to "This term was made obsolete because it is based on a temporal division of the cell cycle." * Changed comment from "This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component terms 'condensed chromosome ; GO:0000793' or its children and 'condensed nuclear chromosome ; GO:0000794' or its children." to "This term was made obsolete because it is based on a temporal division of the cell cycle." * Changed comment from "This term was made obsolete because it is based on a process. To update annotations, consider cellular_component term 'condensed nuclear chromosome ; GO:0000794' or its children." to "This term was made obsolete because it is based on a process." * Changed comment from "This term was made obsolete because more specific terms were created. To update annotations, consider cellular_component term 'proton-transporting ATP synthase complex, coupling factor F(o) ; GO:0045263' or its children." to "This term was made obsolete because more specific terms were created." * Changed comment from "This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric. To update annotations, consider biological_process term 'protein targeting to peroxisome ; GO:0006625' or its children, cellular_component term 'peroxisomal part ; GO:0044439' or its children, and molecular_function term 'peroxisome targeting sequence binding ; GO:0000268' or its children." to "This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric." * Changed comment from "This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself. To update annotations, consider cellular_component terms 'COPI vesicle coat ; GO:0030126' and 'COPI-coated vesicle ; GO:0030137' or its children." to "This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself." * Changed comment from "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider cellular_component term 'ER to Golgi transport vesicle ; GO:0030134' or its children." to "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required." * Changed comment from "This term was made obsolete because it was being used to describe two different components. To update annotations, consider cellular_component terms 'secretory granule ; GO:0030141' or its children and 'transport vesicle ; GO:0030133' or its children." to "This term was made obsolete because it was being used to describe two different components." * Changed comment from "This term was made obsolete because its parent was made obsolete. To update annotations, consider cellular_component terms 'secretory granule membrane ; GO:0030667' or its children and 'transport vesicle membrane ; GO:0030658' or its children." to "This term was made obsolete because its parent was made obsolete." * Changed comment from "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider cellular_component term 'ER to Golgi transport vesicle ; GO:0030134' or its children." to "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required." * Changed comment from "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider cellular_component term 'Golgi to ER transport vesicle ; GO:0030142' or its children." to "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required." * Changed comment from "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles. To update annotations, consider cellular_component term 'transport vesicle ; GO:0030133' or its children." to "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles." * Changed comment from "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, consider cellular_component term 'transport vesicle ; GO:0030133' or its children." to "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required." * Changed comment from "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. To update annotations, use cellular_component term 'endocytic vesicle ; GO:0030139'." to "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required." * Changed comment from "This term was made obsolete because its definition was inaccurate. To update annotations, consider cellular_component terms 'proteasome complex (sensu Eukaryota) ; GO:0000502' or its children, 'proteasome core complex (sensu Bacteria) ; GO:0000503', and 'proteasome regulatory particle (sensu Bacteria) ; GO:0000504'." to "This term was made obsolete because its definition was inaccurate." * Changed comment from "This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product. To update annotations, use cellular_component term 'integral to plasma membrane ; GO:0005887'." to "This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product." * Changed comment from "This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean. To update annotations, use cellular_component term 'AP-type membrane coat adaptor complex ; GO:0030119'." to "This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean." * Changed comment from "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. To update annotations, consider cellular_component term 'AP-1 adaptor complex ; GO:0030121'." to "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous." * Changed comment from "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. To update annotations, consider cellular_component term 'AP-2 adaptor complex ; GO:0030122'." to "This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous." * Changed comment from "This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider cellular_component terms 'mating projection ; GO:0005937' or its children and 'mating projection base ; GO:0001400' and external ontology term 'shmoo ; FAO:0001023'." to "This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'." * Changed comment from "This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex. To update annotations, consider cellular_component term 'isoamylase complex ; GO:0043033' or its children." to "This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component term 'fibrinogen complex ; GO:0005577'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component term 'fibrinogen complex ; GO:0005577'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a single gene product and not a complex. To update annotations, consider cellular_component term 'fibrinogen complex ; GO:0005577'." to "This term was made obsolete because it represents a single gene product and not a complex." * Changed comment from "This term was made obsolete because it represents a function rather than a process. To update annotations, consider molecular_function term 'acetate-CoA ligase activity ; GO:0003987'." to "This term was made obsolete because it represents a function rather than a process." * Changed comment from "This term was made obsolete because it was an unnecessary grouping term. To update annotations, use biological_process term 'electron transport ; GO:0006118'." to "This term was made obsolete because it was an unnecessary grouping term." * Changed comment from "This term was made obsolete because the term string represents a molecular function and not a biological pathway. To update annotations, consider biological_process terms 'electron transport ; GO:0006118' or its children and 'glutathione metabolic process ; GO:0006749' or its children and molecular_function term 'glutathione-disulfide reductase activity ; GO:0004362'." to "This term was made obsolete because the term string represents a molecular function and not a biological pathway." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider biological_process term 'electron transport ; GO:0006118' or its children and molecular_function term 'protein-disulfide reductase (glutathione) activity ; GO:0019153'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because the term string was ambiguous and the term may represent a molecular function. To update annotations, consider biological_process term 'electron transport ; GO:0006118' or its children and molecular_function term '6-phosphofructokinase activity ; GO:0003872'." to "This term was made obsolete because the term string was ambiguous and the term may represent a molecular function." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider biological_process terms 'dihydrolipoamide metabolic process ; GO:0051068' and 'electron transport ; GO:0006118' or its children and molecular_function term 'dihydrolipoyl dehydrogenase activity ; GO:0004148'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider biological_process term 'electron transport ; GO:0006118' or its children and molecular_function term 'dihydrolipoyl dehydrogenase activity ; GO:0004148'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider biological_process terms 'dihydrobiopterin metabolic process ; GO:0051066' and 'electron transport ; GO:0006118' or its children and molecular_function term 'pteridine reductase activity ; GO:0047040'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider biological_process terms 'dihydropteridine metabolic process ; GO:0051067' and 'electron transport ; GO:0006118' or its children and molecular_function term '6,7-dihydropteridine reductase activity ; GO:0004155'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because more appropriate terms were created. To update annotations, consider biological_process terms 'purine base metabolic process ; GO:0006144' or its children, 'purine nucleoside metabolic process ; GO:0042278' or its children, and 'purine nucleotide metabolic process ; GO:0006163' or its children." to "This term was made obsolete because more appropriate terms were created." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, use molecular_function term 'purine nucleosidase activity ; GO:0008477'." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, use molecular_function term 'adenosine deaminase activity ; GO:0004000'." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, use molecular_function term 'deoxyadenosine deaminase activity ; GO:0046936'." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider molecular_function term 'ribonucleoside-diphosphate reductase activity ; GO:0004748' or its children." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, use molecular_function term 'AMP deaminase activity ; GO:0003876'." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider molecular_function term 'ADP reductase activity ; GO:0051061'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because more appropriate terms were created. To update annotations, consider biological_process terms 'pyrimidine base metabolic process ; GO:0006206' or its children, 'pyrimidine nucleoside metabolic process ; GO:0006213' or its children, and 'pyrimidine nucleotide metabolic process ; GO:0006220' or its children." to "This term was made obsolete because more appropriate terms were created." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, use molecular_function term 'uridine kinase activity ; GO:0004849'." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider molecular_function term 'TTP reductase activity ; GO:0051064'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider molecular_function term 'CDP reductase activity ; GO:0051063'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider molecular_function term 'CTP reductase activity ; GO:0051065'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider molecular_function term 'UDP reductase activity ; GO:0051062'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because this process can be subdivided into multiple processes. To update annotations, consider biological_process term 'nucleotide-excision repair ; GO:0006289' or its children." to "This term was made obsolete because this process can be subdivided into multiple processes." * Changed comment from "This term was made obsolete because it is a substrate specific DNA repair process. To update annotations, consider biological_process terms 'nucleotide-excision repair, DNA damage recognition ; GO:0000715' or its children and 'transcription-coupled nucleotide-excision repair, DNA damage recognition ; GO:0000716'." to "This term was made obsolete because it is a substrate specific DNA repair process." * Changed comment from "This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair. To update annotations, consider biological_process terms 'base-excision repair ; GO:0006284' or its children and 'nucleotide-excision repair ; GO:0006289' or its children." to "This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, use molecular_function term 'bent DNA binding ; GO:0003681'." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, consider molecular_function term 'random coil DNA binding ; GO:0003695'." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, use molecular_function term 'AT DNA binding ; GO:0003680'." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, use molecular_function term 'satellite DNA binding ; GO:0003696'." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, use molecular_function term 'single-stranded DNA binding ; GO:0003697'." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it relates to a specific gene family rather than a process. To update annotations, consider biological_process terms 'chromatin silencing ; GO:0006342' or its children and 'chromatin-mediated maintenance of transcription ; GO:0048096'." to "This term was made obsolete because it relates to a specific gene family rather than a process." * Changed comment from "This term was made obsolete because it relates to a specific gene family rather than a process. To update annotations, consider biological_process terms 'chromatin silencing ; GO:0006342' or its children and 'chromatin-mediated maintenance of transcription ; GO:0048096'." to "This term was made obsolete because it relates to a specific gene family rather than a process." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, use molecular_function term 'chromatin insulator sequence binding ; GO:0043035'." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it represents several different processes. To update annotations, consider biological_process terms 'Group I intron splicing ; GO:0000372', 'Group II intron splicing ; GO:0000373', 'Group III intron splicing ; GO:0000374', 'nuclear mRNA splicing, via spliceosome ; GO:0000398' or its children, and 'RNA splicing, via endonucleolytic cleavage and ligation ; GO:0000394' or its children." to "This term was made obsolete because it represents several different processes." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, consider biological_process term 'generation of catalytic spliceosome for second transesterification step ; GO:0000350' or its children and molecular_function term 'second spliceosomal transesterification activity ; GO:0000386' or its children." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, consider biological_process terms 'spliceosomal conformational changes to generate catalytic conformation ; GO:0000393' or its children and 'spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) ; GO:0000388' or its children and molecular_function term 'second spliceosomal transesterification activity ; GO:0000386' or its children." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene. To update annotations, consider biological_process term 'assembly of spliceosomal tri-snRNP ; GO:0000244' or its children." to "This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, consider molecular_function term 'poly(A) binding ; GO:0008143'." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA. To update annotations, consider biological_process term 'tRNA splicing ; GO:0006388'." to "This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, use molecular_function term 'aminoacyl-tRNA hydrolase activity ; GO:0004045'." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it represents a function rather than a process. To update annotations, consider molecular_function term 'RNA cap binding ; GO:0000339' or its children." to "This term was made obsolete because it represents a function rather than a process." * Changed comment from "This term was made obsolete because it represents a function rather than a process. To update annotations, consider cellular_component term 'endoplasmic reticulum ; GO:0005783' or its children and molecular_function term 'unfolded protein binding ; GO:0051082'." to "This term was made obsolete because it represents a function rather than a process." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, consider molecular_function term 'peptidyl-prolyl cis-trans isomerase activity ; GO:0003755' or its children." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown. To update annotations, consider biological_process terms 'chaperone-mediated protein complex assembly ; GO:0051131' and 'protein folding ; GO:0006457' or its children." to "This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown." * Changed comment from "This term was made obsolete because it presents a molecular function. To update annotations, use molecular_function term 'protein disulfide isomerase activity ; GO:0003756'." to "This term was made obsolete because it presents a molecular function." * Changed comment from "This term was made obsolete because it is a redundant grouping term. To update annotations, consider biological_process terms 'peptidyl-asparagine hydroxylation ; GO:0042265' or its children and 'peptidyl-aspartic acid hydroxylation ; GO:0042264' or its children." to "This term was made obsolete because it is a redundant grouping term." * Changed comment from "This term was made obsolete because it represents a single activity. To update annotations, consider molecular_function term 'protein disulfide isomerase activity ; GO:0003756'." to "This term was made obsolete because it represents a single activity." * Changed comment from "This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. To update annotations, use biological_process term 'protein amino acid prenylation ; GO:0018346'." to "This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein." * Changed comment from "This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. To update annotations, use biological_process term 'protein amino acid farnesylation ; GO:0018347'." to "This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein." * Changed comment from "This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. To update annotations, use biological_process term 'protein amino acid geranylgeranylation ; GO:0018348'." to "This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein." * Changed comment from "This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation. To update annotations, consider biological_process term 'protein targeting to mitochondrion ; GO:0006626' or its children." to "This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, consider molecular_function term 'lipid binding ; GO:0008289' or its children." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process. To update annotations, use molecular_function term 'ecdysone 20-monooxygenase activity ; GO:0004501'." to "This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, consider molecular_function term 'juvenile hormone binding ; GO:0005500'." to "This term was made obsolete because it represents a molecular function and not a biological process." * Changed comment from "This term was made obsolete because it was replaced by more specific terms. To update annotations, consider biological_process terms 'coenzyme metabolic process ; GO:0006732' or its children and 'prosthetic group metabolic process ; GO:0051189' or its children." to "This term was made obsolete because it was replaced by more specific terms." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider biological_process term 'dihydrofolate metabolic process ; GO:0046452' or its children and molecular_function term 'dihydrofolate reductase activity ; GO:0004146'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function rather than a biological process. To update annotations, consider biological_process term 'cobalamin metabolic process ; GO:0009235' or its children and molecular_function term 'cob(II)alamin reductase activity ; GO:0050453'." to "This term was made obsolete because it represents a molecular function rather than a biological process." * Changed comment from "This term was made obsolete because it represents a molecular function. To update annotations, consider molecular_function term 'catalase activity ; GO:0004096'." to "This term was made obsolete because it represents a molecular function." * Changed comment from "This term was made obsolete because it represents a molecular function and not a biological process. To update annotations, use molecular_function term 'glutathione transferase activity ; GO:0004364'." to "This term was made obsolete because it represents a molecular function and not a bio