[Go-diff] GO update 08/15/2008

Fri Aug 15 21:30:47 PDT 2008

OBODIFF of gene_ontology_write.obo version 1.166 by 1.168

Starting obodiff at /share/go/bin/oboedit/current using 256M of memory
* Created object of type obo:TERM with id GO:0060277
* Created object of type obo:TERM with id GO:0060278
* Created object of type obo:TERM with id GO:0060279
* Created object of type obo:TERM with id GO:0060280
* Created object of type obo:TERM with id GO:0060281
* Created object of type obo:TERM with id GO:0060282
* Created object of type obo:TERM with id GO:0060283
* Created object of type obo:TERM with id GO:0060284
* Created object of type obo:TERM with id GO:0070001
* Created object of type obo:TERM with id GO:0070002
* Created object of type obo:TERM with id GO:0070003
* Created object of type obo:TERM with id GO:0070004
* Created object of type obo:TERM with id GO:0070005
* Created object of type obo:TERM with id GO:0070006
* Created object of type obo:TERM with id GO:0070007
* Created object of type obo:TERM with id GO:0070008
* Created object of type obo:TERM with id GO:0070009
* Created object of type obo:TERM with id GO:0070010
* Created object of type obo:TERM with id GO:0070011
* Created object of type obo:TERM with id GO:0070012
* Populated new object GO:0060277 (macro)
  * Changed name of GO:0060277 from "<new term>" to "negative regulation of transcription during G1 phase of mitotic cell cycle"
  * Set definition of GO:0060277 to "Any process that stop, prevents or decreases transcription during the G1 phase of the mitotic cell cycle."
  * Added definition dbxref GOC:dph to GO:0060277
  * Added definition dbxref GOC:tb to GO:0060277
  * Added synonym "negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle" to GO:0060277
  * Added general dbxref GOC:tb to synonym negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle of GO:0060277
  * Added general dbxref GOC:dph to synonym negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle of GO:0060277
  * Copied GO:0060277 to GO:0000114 with type OBO_REL:is_a
  * Copied GO:0060277 to GO:0006366 with type negatively_regulates
  * Copied GO:0060277 to GO:0000122 with type OBO_REL:is_a
  * Assigned namespace "biological_process" to GO:0060277
* Populated new object GO:0060278 (macro)
  * Changed name of GO:0060278 from "<new term>" to "regulation of ovulation"
  * Set definition of GO:0060278 to "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary."
  * Added definition dbxref GOC:dph to GO:0060278
  * Added definition dbxref GOC:kva to GO:0060278
  * Added definition dbxref GOC:tb to GO:0060278
  * Copied GO:0060278 to GO:0030728 with type regulates
  * Copied GO:0060278 to GO:0051239 with type OBO_REL:is_a
  * Assigned namespace "biological_process" to GO:0060278
* Populated new object GO:0060279 (macro)
  * Changed name of GO:0060279 from "<new term>" to "positive regulation of ovulation"
  * Set definition of GO:0060279 to "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary."
  * Added definition dbxref GOC:dph to GO:0060279
  * Added definition dbxref GOC:kva to GO:0060279
  * Added definition dbxref GOC:tb to GO:0060279
  * Copied GO:0060279 to GO:0051240 with type OBO_REL:is_a
  * Copied GO:0060279 to GO:0060278 with type OBO_REL:is_a
  * Copied GO:0060279 to GO:0030728 with type positively_regulates
  * Assigned namespace "biological_process" to GO:0060279
* Populated new object GO:0060280 (macro)
  * Changed name of GO:0060280 from "<new term>" to "negative regulation of ovulation"
  * Set definition of GO:0060280 to "Any process that stops, prevents or reduces the frequency, rate or extent
of ovulation, the release of a mature ovum/oocyte from an ovary."
  * Added definition dbxref GOC:dph to GO:0060280
  * Added definition dbxref GOC:kva to GO:0060280
  * Added definition dbxref GOC:tb to GO:0060280
  * Copied GO:0060280 to GO:0051241 with type OBO_REL:is_a
  * Copied GO:0060280 to GO:0030728 with type negatively_regulates
  * Copied GO:0060280 to GO:0060278 with type OBO_REL:is_a
  * Assigned namespace "biological_process" to GO:0060280
* Populated new object GO:0060281 (macro)
  * Changed name of GO:0060281 from "<new term>" to "regulation of oocyte development"
  * Set definition of GO:0060281 to "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell."
  * Added definition dbxref GOC:dph to GO:0060281
  * Added definition dbxref GOC:tb to GO:0060281
  * Added definition dbxref PMID:2394318 to GO:0060281
  * Copied GO:0060281 to GO:0060284 with type OBO_REL:is_a
  * Copied GO:0060281 to GO:0048599 with type regulates
  * Assigned namespace "biological_process" to GO:0060281
* Populated new object GO:0060282 (macro)
  * Changed name of GO:0060282 from "<new term>" to "positive regulation of oocyte development"
  * Set definition of GO:0060282 to "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell."
  * Added definition dbxref GOC:dph to GO:0060282
  * Added definition dbxref GOC:tb to GO:0060282
  * Copied GO:0060282 to GO:0060281 with type OBO_REL:is_a
  * Copied GO:0060282 to GO:0048599 with type positively_regulates
  * Assigned namespace "biological_process" to GO:0060282
* Populated new object GO:0060283 (macro)
  * Changed name of GO:0060283 from "<new term>" to "negative regulation of oocyte development"
  * Set definition of GO:0060283 to "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell."
  * Added definition dbxref GOC:dph to GO:0060283
  * Added definition dbxref GOC:tb to GO:0060283
  * Copied GO:0060283 to GO:0060281 with type OBO_REL:is_a
  * Copied GO:0060283 to GO:0048599 with type negatively_regulates
  * Assigned namespace "biological_process" to GO:0060283
* Populated new object GO:0060284 (macro)
  * Changed name of GO:0060284 from "<new term>" to "regulation of cell development"
  * Set definition of GO:0060284 to "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate."
  * Added definition dbxref GOC:dph to GO:0060284
  * Added definition dbxref GOC:tb to GO:0060284
  * Copied GO:0060284 to GO:0048468 with type regulates
  * Copied GO:0060284 to GO:0050794 with type OBO_REL:is_a
  * Assigned namespace "biological_process" to GO:0060284
* Populated new object GO:0070001 (macro)
  * Changed name of GO:0070001 from "<new term>" to "aspartic-type peptidase activity"
  * Set definition of GO:0070001 to "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."
  * Added definition dbxref GOC:mah to GO:0070001
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070001
  * Copied GO:0070001 to GO:0070011 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070001
* Populated new object GO:0070002 (macro)
  * Changed name of GO:0070002 from "<new term>" to "glutamic-type peptidase activity"
  * Set definition of GO:0070002 to "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."
  * Added definition dbxref GOC:mah to GO:0070002
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070002
  * Copied GO:0070002 to GO:0070011 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070002
* Populated new object GO:0070003 (macro)
  * Changed name of GO:0070003 from "<new term>" to "threonine-type peptidase activity"
  * Set definition of GO:0070003 to "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile."
  * Added definition dbxref GOC:mah to GO:0070003
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070003
  * Copied GO:0070003 to GO:0070011 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070003
* Populated new object GO:0070004 (macro)
  * Changed name of GO:0070004 from "<new term>" to "cysteine-type exopeptidase activity"
  * Set definition of GO:0070004 to "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."
  * Added definition dbxref GOC:mah to GO:0070004
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070004
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE to GO:0070004
  * Copied GO:0070004 to GO:0008234 with type OBO_REL:is_a
  * Copied GO:0070004 to GO:0008238 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070004
* Populated new object GO:0070005 (macro)
  * Changed name of GO:0070005 from "<new term>" to "cysteine-type aminopeptidase activity"
  * Set definition of GO:0070005 to "Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."
  * Added definition dbxref GOC:mah to GO:0070005
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE to GO:0070005
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070005
  * Added general dbxref EC:3.4.18 to GO:0070005
  * Copied GO:0070005 to GO:0004177 with type OBO_REL:is_a
  * Copied GO:0070005 to GO:0070004 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070005
* Populated new object GO:0070006 (macro)
  * Changed name of GO:0070006 from "<new term>" to "metalloaminopeptidase activity"
  * Set definition of GO:0070006 to "Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."
  * Added definition dbxref GOC:mah to GO:0070006
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE to GO:0070006
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070006
  * Copied GO:0070006 to GO:0004177 with type OBO_REL:is_a
  * Copied GO:0070006 to GO:0008235 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070006
* Populated new object GO:0070007 (macro)
  * Changed name of GO:0070007 from "<new term>" to "glutamic-type endopeptidase activity"
  * Set definition of GO:0070007 to "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."
  * Added definition dbxref GOC:mah to GO:0070007
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070007
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE to GO:0070007
  * Copied GO:0070007 to GO:0004175 with type OBO_REL:is_a
  * Copied GO:0070007 to GO:0070002 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070007
* Populated new object GO:0070008 (macro)
  * Changed name of GO:0070008 from "<new term>" to "serine-type exopeptidase activity"
  * Set definition of GO:0070008 to "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."
  * Added definition dbxref GOC:mah to GO:0070008
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070008
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE to GO:0070008
  * Added definition dbxref ISBN:0716720094 to GO:0070008
  * Added general dbxref EC:3.4.21 to GO:0070008
  * Added general dbxref Reactome:1683 to GO:0070008
  * Added GO:0070008 to category gosubset_prok
  * Copied GO:0070008 to GO:0008236 with type OBO_REL:is_a
  * Copied GO:0070008 to GO:0008238 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070008
* Populated new object GO:0070009 (macro)
  * Changed name of GO:0070009 from "<new term>" to "serine-type aminopeptidase activity"
  * Set definition of GO:0070009 to "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."
  * Added definition dbxref GOC:mah to GO:0070009
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE to GO:0070009
  * Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0070009
  * Added definition dbxref ISBN:0716720094 to GO:0070009
  * Copied GO:0070009 to GO:0004177 with type OBO_REL:is_a
  * Copied GO:0070009 to GO:0070008 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070009
* Populated new object GO:0070010 (macro)
  * Changed name of GO:0070010 from "<new term>" to "peptidase activity, acting on D-amino acid peptides"
  * Set definition of GO:0070010 to "Catalysis of the hydrolysis of peptide bonds formed between D-amino acids."
  * Added definition dbxref GOC:mah to GO:0070010
  * Copied GO:0070010 to GO:0008233 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070010
* Populated new object GO:0070011 (macro)
  * Changed name of GO:0070011 from "<new term>" to "peptidase activity, acting on L-amino acid peptides"
  * Set definition of GO:0070011 to "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids."
  * Added definition dbxref GOC:mah to GO:0070011
  * Copied GO:0070011 to GO:0008233 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070011
* Populated new object GO:0070012 (macro)
  * Changed name of GO:0070012 from "<new term>" to "oligopeptidase activity"
  * Set definition of GO:0070012 to "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds."
  * Added definition dbxref GOC:mah to GO:0070012
  * Added definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) to GO:0070012
  * Copied GO:0070012 to GO:0008233 with type OBO_REL:is_a
  * Assigned namespace "molecular_function" to GO:0070012
* Changed name of GO:0000083 from "G1/S-specific transcription in mitotic cell cycle" to "regulation of transcription of G1/S-phase of mitotic cell cycle"
* Added definition dbxref GOC:dph to GO:0000083
* Added definition dbxref GOC:tb to GO:0000083
* Added synonym "G1/S-specific transcription in mitotic cell cycle" to GO:0000083
* Added synonym "regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle" to GO:0000083
* Changed name of GO:0000114 from "G1-specific transcription in mitotic cell cycle" to "regulation of transcription during G1 phase of mitotic cell cycle"
* Added definition dbxref GOC:dph to GO:0000114
* Added definition dbxref GOC:tb to GO:0000114
* Added synonym "G1-specific transcription in mitotic cell cycle" to GO:0000114
* Added synonym "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle>" to GO:0000114
* Changed synonym scope of GO:0000114 from "Related" to "Exact"
* Changed name of GO:0000115 from "S-phase-specific transcription in mitotic cell cycle" to "regulation of transcription during S-phase of mitotic cell cycle"
* Added definition dbxref GOC:dph to GO:0000115
* Added definition dbxref GOC:tb to GO:0000115
* Added synonym "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" to GO:0000115
* Added synonym "S-phase-specific transcription in mitotic cell cycle" to GO:0000115
* Changed name of GO:0000116 from "G2-specific transcription in mitotic cell cycle" to "regulation of transcription during G2-phase of mitotic cell cycle"
* Added definition dbxref GOC:dph to GO:0000116
* Added definition dbxref GOC:tb to GO:0000116
* Added synonym "G2-specific transcription in mitotic cell cycle" to GO:0000116
* Added synonym "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" to GO:0000116
* Changed name of GO:0000117 from "G2/M-specific transcription in mitotic cell cycle" to "regulation of transcription during G2/M-phase of mitotic cell cycle"
* Added definition dbxref GOC:dph to GO:0000117
* Added definition dbxref GOC:tb to GO:0000117
* Added synonym "G2/M-specific transcription in mitotic cell cycle" to GO:0000117
* Added synonym "regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle" to GO:0000117
* Changed name of GO:0000767 from "cellular morphogenesis during conjugation" to "cell morphogenesis during conjugation"
* Changed name of GO:0000904 from "cellular morphogenesis during differentiation" to "cell morphogenesis during differentiation"
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0001509 from "Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." to "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds."
* Deleted GO:0001509 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1f5abf8
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003802 from "Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." to "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta."
* Deleted GO:0003802 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1ed5b13
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003803 from "Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." to "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa."
* Deleted GO:0003803 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1f66fa5
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003804 from "Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." to "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)."
* Deleted GO:0003804 --OBO_REL:is_a--> GO:0004252
* Deleted GO:0003804 --OBO_REL:is_a--> GO:0030567
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1bf51d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003805 from "Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." to "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa."
* Deleted GO:0003805 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1795fb2
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003806 from "Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." to "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa."
* Deleted GO:0003806 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 179b984
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003807 from "Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." to "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin."
* Deleted GO:0003807 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 82bd28
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003808 from "Catalysis of the degradation of blood coagulation factors Va and VIIIa." to "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa."
* Deleted GO:0003808 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1509ab0
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003809 from "Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." to "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B."
* Deleted GO:0003809 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at dbd916
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003812 from "Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." to "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b."
* Deleted GO:0003812 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1894f7d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003813 from "Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." to "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b."
* Deleted GO:0003813 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1c1a5aa
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003815 from "Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." to "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)."
* Deleted GO:0003815 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 6366db
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003816 from "Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." to "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)."
* Deleted GO:0003816 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1f5dc11
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003817 from "Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." to "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)."
* Deleted GO:0003817 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 43114f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0003818 from "Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." to "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage."
* Deleted GO:0003818 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1255cbf
* Changed definition of GO:0004175 from "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites." to "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain."
* Deleted definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) from GO:0004175
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE to GO:0004175
* Deleted GO:0004175 --OBO_REL:is_a--> GO:0008233
* Copied GO:0004175 to GO:0070011 with type OBO_REL:is_a
* Deleted GO:0004176 --OBO_REL:is_a--> GO:0008233
* Copied GO:0004176 to GO:0070011 with type OBO_REL:is_a
* Changed definition of GO:0004177 from "Catalysis of the hydrolysis of N-terminal amino acid residues from oligopeptides or polypeptides." to "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain."
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004178 from "Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." to "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro."
* Deleted GO:0004178 --OBO_REL:is_a--> GO:0008235
* Deleted GO:0004178 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1ec0e8b
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004179 from "Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." to "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide."
* Deleted GO:0004179 --OBO_REL:is_a--> GO:0008235
* Deleted GO:0004179 --OBO_REL:is_a--> GO:0016284
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at af0949
* Changed definition of GO:0004180 from "Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." to "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide."
* Changed definition of GO:0004181 from "Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism." to "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE to GO:0004181
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0004181
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004182 from "Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." to "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro."
* Deleted GO:0004182 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 18aca3c
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004183 from "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." to "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents."
* Deleted GO:0004183 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at e352f6
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004184 from "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." to "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma."
* Deleted GO:0004184 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 5bcd5a
* Changed name of GO:0004185 from "serine carboxypeptidase activity" to "serine-type carboxypeptidase activity"
* Changed definition of GO:0004185 from "Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." to "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."
* Deleted definition dbxref EC:3.4.16.- from GO:0004185
* Deleted definition dbxref http://en.wikipedia.org/wiki/Serine_hydrolase from GO:0004185
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE to GO:0004185
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0004185
* Added definition dbxref ISBN:0716720094 to GO:0004185
* Added synonym "serine carboxypeptidase activity" to GO:0004185
* Changed synonym scope of GO:0004185 from "Related" to "Exact"
* Deleted GO:0004185 --OBO_REL:is_a--> GO:0008236
* Copied GO:0004185 to GO:0070008 with type OBO_REL:is_a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004186 from "Catalysis of the release of a C-terminal amino acid with a broad specificity." to "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity."
* Deleted GO:0004186 --OBO_REL:is_a--> GO:0004185
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 106d713
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004187 from "Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." to "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents."
* Deleted GO:0004187 --OBO_REL:is_a--> GO:0004185
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 12377d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004188 from "Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." to "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid."
* Deleted GO:0004188 --OBO_REL:is_a--> GO:0008322
* Deleted GO:0004188 --OBO_REL:is_a--> GO:0004185
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1f8fdf0
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004189 from "Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." to "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr."
* Deleted GO:0004189 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at e93a1b
* Changed definition of GO:0004190 from "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." to "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."
* Copied GO:0004190 to GO:0070001 with type OBO_REL:is_a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004191 from "Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." to "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor."
* Deleted GO:0004191 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 2e5bfe
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004192 from "Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin."
* Deleted GO:0004192 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 199a19d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004193 from "Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity."
* Deleted GO:0004193 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1415cad
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004194 from "Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin."
* Deleted GO:0004194 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 2b803f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004195 from "Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." to "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I."
* Deleted GO:0004195 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1f0c902
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004196 from "Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." to "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24."
* Deleted GO:0004196 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 11cd79d
* Changed definition of GO:0004197 from "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center." to "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."
* Deleted definition dbxref EC:3.4.22.- from GO:0004197
* Deleted definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) from GO:0004197
* Added definition dbxref GOC:mah to GO:0004197
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0004197
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE to GO:0004197
* Changed definition of GO:0004198 from "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." to "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium."
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004213 from "Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides."
* Deleted GO:0004213 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 8fbe6f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004214 from "Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." to "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro."
* Deleted GO:0004214 --OBO_REL:is_a--> GO:0008239
* Deleted GO:0004214 --OBO_REL:is_a--> GO:0008234
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 11f780f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004215 from "Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase."
* Deleted GO:0004215 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 10331c6
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004216 from "Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg."
* Deleted GO:0004216 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at b8cafe
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004217 from "Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity."
* Deleted GO:0004217 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 16fa7a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004218 from "Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds."
* Deleted GO:0004218 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 968282
* Changed comment from "Note that pyroglutamic acid has sometimes been referred to as 5-oxoproline." to "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004219 from "Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." to "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide."
* Deleted GO:0004219 --OBO_REL:is_a--> GO:0008234
* Deleted GO:0004219 --OBO_REL:is_a--> GO:0016920
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 15245ee
* Changed definition of GO:0004222 from "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites." to "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."
* Deleted definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) from GO:0004222
* Added definition dbxref GOC:mah to GO:0004222
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0004222
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE to GO:0004222
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004226 from "Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." to "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa."
* Deleted GO:0004226 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 6d3a12
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004228 from "Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." to "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond."
* Deleted GO:0004228 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at ff887a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004229 from "Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." to "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V."
* Deleted GO:0004229 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 590f6e
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004230 from "Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." to "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide."
* Deleted GO:0004230 --OBO_REL:is_a--> GO:0008235
* Deleted GO:0004230 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1043f90
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004231 from "Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." to "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins."
* Deleted GO:0004231 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1e90b8f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004232 from "Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." to "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue."
* Deleted GO:0004232 --OBO_REL:is_a--> GO:0008133
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at f615c3
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004234 from "Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." to "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin."
* Deleted GO:0004234 --OBO_REL:is_a--> GO:0004222
* Deleted GO:0004234 --OBO_REL:is_a--> GO:0042708
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at ec0fb
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004235 from "Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." to "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)."
* Deleted GO:0004235 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 9fdb4a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004237 from "Catalysis of the hydrolysis of dipeptides." to "OBSOLETE. Catalysis of the hydrolysis of dipeptides."
* Deleted GO:0004237 --OBO_REL:is_a--> GO:0008235
* Deleted GO:0004237 --OBO_REL:is_a--> GO:0016805
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at f5f972
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004238 from "Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." to "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues."
* Deleted GO:0004238 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at cbb203
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004239 from "Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." to "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides."
* Deleted GO:0004239 --OBO_REL:is_a--> GO:0008235
* Deleted GO:0004239 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 11418b5
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004240 from "Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." to "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2."
* Deleted GO:0004240 --OBO_REL:is_a--> GO:0004222
* Deleted GO:0004240 --OBO_REL:is_a--> GO:0009003
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 621de2
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004243 from "Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." to "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion."
* Deleted GO:0004243 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1980ec9
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004244 from "Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." to "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space."
* Deleted GO:0004244 --OBO_REL:is_a--> GO:0004175
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1f2df26
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004245 from "Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." to "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides."
* Deleted GO:0004245 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 18754f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004246 from "Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." to "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II."
* Deleted GO:0004246 --OBO_REL:is_a--> GO:0008237
* Deleted GO:0004246 --OBO_REL:is_a--> GO:0008241
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1bdcbf3
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004247 from "Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." to "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds."
* Deleted GO:0004247 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 198f5c7
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004248 from "Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." to "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues."
* Deleted GO:0004248 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1301a2f
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0004249 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0004249
* Deleted GO:0004249 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 10718c9
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004250 from "Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." to "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates."
* Deleted GO:0004250 --OBO_REL:is_a--> GO:0004177
* Deleted GO:0004250 --OBO_REL:is_a--> GO:0008235
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at ec3ee8
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004251 from "Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." to "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro."
* Deleted GO:0004251 --OBO_REL:is_a--> GO:0016805
* Deleted GO:0004251 --OBO_REL:is_a--> GO:0008235
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 15f3de
* Changed definition of GO:0004252 from "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." to "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."
* Deleted definition dbxref http://en.wikipedia.org/wiki/Serine_hydrolase from GO:0004252
* Deleted definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) from GO:0004252
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0004252
* Added definition dbxref ISBN:0716720094 to GO:0004252
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004253 from "Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." to "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide."
* Deleted GO:0004253 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 13d8d82
* Changed definition of GO:0004254 from "Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." to "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide."
* Deleted GO:0004254 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 15723d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004261 from "Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C."
* Deleted GO:0004261 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1ff3519
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004262 from "Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." to "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides."
* Deleted GO:0004262 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1f734ba
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004263 from "Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." to "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa."
* Deleted GO:0004263 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at a6a67f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004274 from "Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." to "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline."
* Deleted GO:0004274 --OBO_REL:is_a--> GO:0008239
* Deleted GO:0004274 --OBO_REL:is_a--> GO:0008236
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at fd0d6b
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004275 from "Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." to "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen."
* Deleted GO:0004275 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 17c1b7e
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004276 from "Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." to "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors."
* Deleted GO:0004276 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at f1234c
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004277 from "Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." to "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates."
* Deleted GO:0004277 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1447d1e
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004278 from "Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." to "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa."
* Deleted GO:0004278 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 172684e
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004281 from "Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." to "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin."
* Deleted GO:0004281 --OBO_REL:is_a--> GO:0008132
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1ddaa6
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004283 from "Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." to "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products."
* Deleted GO:0004283 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1fdef54
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004284 from "Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." to "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa."
* Deleted GO:0004284 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 6b9291
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004285 from "Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." to "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond."
* Deleted GO:0004285 --OBO_REL:is_a--> GO:0016808
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 637c2a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004286 from "Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." to "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond."
* Deleted GO:0004286 --OBO_REL:is_a--> GO:0016808
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 16cd7c2
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004287 from "Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." to "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides."
* Deleted GO:0004287 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at c91f02
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0004289 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0004289
* Deleted GO:0004289 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 12c904
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004290 from "Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." to "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors."
* Deleted GO:0004290 --OBO_REL:is_a--> GO:0004289
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 14b446b
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004291 from "Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." to "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides."
* Deleted GO:0004291 --OBO_REL:is_a--> GO:0004289
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 7908f6
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004293 from "Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." to "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds."
* Deleted GO:0004293 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 3b5f21
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004294 from "Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." to "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH."
* Deleted GO:0004294 --OBO_REL:is_a--> GO:0008240
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1e2a603
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0004295 from "Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." to "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa."
* Deleted GO:0004295 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1014023
* Changed name of GO:0004298 from "threonine endopeptidase activity" to "threonine-type endopeptidase activity"
* Changed definition of GO:0004298 from "Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles." to "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile."
* Deleted definition dbxref EC:3.4.25.1 from GO:0004298
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0004298
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE to GO:0004298
* Added synonym "threonine endopeptidase activity" to GO:0004298
* Changed synonym scope of GO:0004298 from "Related" to "Exact"
* Copied GO:0004298 to GO:0070003 with type OBO_REL:is_a
* Changed definition of GO:0004866 from "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides." to "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides."
* Changed definition of GO:0004867 from "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme." to "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme."
* Changed definition of GO:0005882 from "A distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: keratin filaments of mammalian epithelial cells; desmin filaments found in cells of muscles of all types; vimentin filaments found in mesenchymal cells; neurofilaments of neurons; and glial filaments found in all types of glial cells." to "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins;  Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filamentss; and Type V, lamins."
* Added definition dbxref http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm to GO:0005882
* Deleted GO:0006308 --OBO_REL:is_a--> GO:0044248
* Copied GO:0006308 to GO:0044265 with type OBO_REL:is_a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008125 from "Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." to "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa."
* Deleted GO:0008125 --OBO_REL:is_a--> GO:0008132
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 119c6a8
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008129 from "Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." to "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'."
* Deleted GO:0008129 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1415092
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008130 from "Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." to "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I."
* Deleted GO:0008130 --OBO_REL:is_a--> GO:0008133
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 110b353
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008132 from "Catalysis of the hydrolysis of proteins, including elastin." to "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin."
* Deleted GO:0008132 --OBO_REL:is_a--> GO:0004252
* Deleted GO:0008132 --OBO_REL:is_a--> GO:0042708
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 16d18f2
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0008133 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0008133
* Deleted GO:0008133 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 180f72c
* Changed definition of GO:0008191 from "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity." to "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."
* Changed definition of GO:0008233 from "Catalysis of the hydrolysis of peptide bonds." to "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid."
* Added definition dbxref ISBN:0815332181 to GO:0008233
* Added synonym "proteinase activity" to GO:0008233
* Changed synonym scope of GO:0008233 from "Related" to "Exact"
* Changed definition of GO:0008234 from "Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center." to "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."
* Deleted definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) from GO:0008234
* Added definition dbxref GOC:mah to GO:0008234
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0008234
* Deleted GO:0008234 --OBO_REL:is_a--> GO:0008233
* Copied GO:0008234 to GO:0070011 with type OBO_REL:is_a
* Changed definition of GO:0008235 from "Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites." to "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."
* Deleted definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) from GO:0008235
* Added definition dbxref GOC:mah to GO:0008235
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0008235
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE to GO:0008235
* Changed definition of GO:0008236 from "Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." to "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."
* Deleted definition dbxref http://en.wikipedia.org/wiki/Serine_hydrolase from GO:0008236
* Deleted definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) from GO:0008236
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0008236
* Added definition dbxref ISBN:0716720094 to GO:0008236
* Deleted GO:0008236 --OBO_REL:is_a--> GO:0008233
* Copied GO:0008236 to GO:0070011 with type OBO_REL:is_a
* Set definition of GO:0008237 to "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."
* Added definition dbxref GOC:mah to GO:0008237
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0008237
* Deleted GO:0008237 --OBO_REL:is_a--> GO:0008233
* Copied GO:0008237 to GO:0070011 with type OBO_REL:is_a
* Changed definition of GO:0008238 from "Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases." to "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both."
* Deleted definition dbxref Dorland's Illustrated Medical Dictionary (ISBN:0721662544) from GO:0008238
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE to GO:0008238
* Deleted GO:0008238 --OBO_REL:is_a--> GO:0008233
* Copied GO:0008238 to GO:0070011 with type OBO_REL:is_a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008243 from "Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." to "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin."
* Deleted GO:0008243 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1e3862b
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0008319 to "OBSOLETE (was not defined before being made obsolete)."
* Added definition dbxref GOC:mah to GO:0008319
* Deleted GO:0008319 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 7dac7d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008322 from "Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." to "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid."
* Deleted GO:0008322 --OBO_REL:is_a--> GO:0004180
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at c77302
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008423 from "Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." to "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred."
* Deleted GO:0008423 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 4f8edb
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008439 from "Increases the activity of the enzyme monophenol monooxygenase." to "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase."
* Deleted GO:0008439 --OBO_REL:is_a--> GO:0004252
* Deleted GO:0008439 --OBO_REL:is_a--> GO:0008047
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 6369b0
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008450 from "Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." to "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated."
* Deleted GO:0008450 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at afc0c9
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008451 from "Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." to "OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide."
* Deleted GO:0008451 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 99dde9
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008462 from "Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." to "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)."
* Deleted GO:0008462 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1b80d21
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008464 from "Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." to "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid."
* Deleted GO:0008464 --OBO_REL:is_a--> GO:0008242
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 660d14
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008472 from "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." to "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid."
* Deleted GO:0008472 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1e4c027
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0008487 to "OBSOLETE (was not defined before being made obsolete)."
* Added definition dbxref GOC:mah to GO:0008487
* Deleted GO:0008487 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1036c7f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008533 from "Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'."
* Deleted GO:0008533 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1c814ba
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008581 from "Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." to "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin."
* Deleted GO:0008581 --OBO_REL:is_a--> GO:0004221
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at c8e634
* Deleted GO:0008594 --OBO_REL:is_a--> GO:0042461
* Copied GO:0008594 to GO:0042461 with type part_of
* Copied GO:0008594 to GO:0000904 with type OBO_REL:is_a
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0008717 to "OBSOLETE (was not defined before being made obsolete)."
* Added definition dbxref GOC:mah to GO:0008717
* Deleted GO:0008717 --OBO_REL:is_a--> GO:0004175
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1817f19
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008769 from "Catalysis of the hydrolysis of Xaa-His dipeptides." to "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides."
* Deleted GO:0008769 --OBO_REL:is_a--> GO:0016805
* Deleted GO:0008769 --OBO_REL:is_a--> GO:0008235
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at bf5798
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008846 from "Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." to "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP."
* Deleted GO:0008846 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at ff809
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0008931 to "OBSOLETE (was not defined before being made obsolete)."
* Added definition dbxref GOC:mah to GO:0008931
* Deleted GO:0008931 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 6536b4
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008944 from "Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." to "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5."
* Deleted GO:0008944 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at ea68c0
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008945 from "Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." to "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline."
* Deleted GO:0008945 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 183544b
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008947 from "Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." to "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys."
* Deleted GO:0008947 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1132258
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008956 from "Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." to "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly."
* Deleted GO:0008956 --OBO_REL:is_a--> GO:0008241
* Deleted GO:0008956 --OBO_REL:is_a--> GO:0008235
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 133fa6d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008975 from "Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." to "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon."
* Deleted GO:0008975 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 17e421d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008978 from "Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." to "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine."
* Deleted GO:0008978 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 26b71a
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0008981 to "OBSOLETE (was not defined before being made obsolete)."
* Added definition dbxref GOC:mah to GO:0008981
* Deleted GO:0008981 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1bf31fe
* Added comment "This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products."
* Changed definition of GO:0008991 from "Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." to "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism."
* Deleted GO:0008991 --OBO_REL:is_a--> GO:0009003
* Deleted GO:0008991 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 16b353c
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0008992 from "Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." to "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA."
* Deleted GO:0008992 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1741dd9
* Added comment "This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products."
* Changed definition of GO:0009003 from "Catalysis of the cleavage of a signal peptide from a protein precursor." to "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor."
* Removed GO:0009003 from category gosubset_prok
* Deleted GO:0009003 --OBO_REL:is_a--> GO:0008233
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 53af06
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0009004 from "Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." to "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor."
* Deleted GO:0009004 --OBO_REL:is_a--> GO:0004252
* Deleted GO:0009004 --OBO_REL:is_a--> GO:0009003
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 7ef9a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0009005 from "Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." to "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group."
* Deleted GO:0009005 --OBO_REL:is_a--> GO:0009049
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 103a0ec
* Added comment "This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products."
* Changed definition of GO:0009049 from "Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." to "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism."
* Deleted GO:0009049 --OBO_REL:is_a--> GO:0004190
* Deleted GO:0009049 --OBO_REL:is_a--> GO:0009003
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 139f2c8
* Deleted GO:0009164 --OBO_REL:is_a--> GO:0044248
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0009377 from "Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." to "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins."
* Deleted GO:0009377 --OBO_REL:is_a--> GO:0008233
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 17247df
* Added comment "This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined."
* Changed definition of GO:0009980 from "Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." to "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups."
* Deleted GO:0009980 --OBO_REL:is_a--> GO:0004180
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1cc95b4
* Added comment "This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined."
* Changed definition of GO:0009983 from "Catalysis of the release of N-terminal tyrosine from a peptide." to "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide."
* Deleted GO:0009983 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 787d25
* Changed definition of GO:0010466 from "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide linkages within proteins." to "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins."
* Deleted GO:0016047 --OBO_REL:is_a--> GO:0016046
* Added comment "This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined."
* Changed definition of GO:0016284 from "Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." to "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide."
* Deleted GO:0016284 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 601095
* Added comment "This term was made obsolete because it represents a gene product and refers to cellular component information."
* Changed definition of GO:0016285 from "Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." to "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides."
* Deleted GO:0016285 --OBO_REL:is_a--> GO:0008235
* Deleted GO:0016285 --OBO_REL:is_a--> GO:0016284
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at e0d280
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0016511 to "OBSOLETE (was not defined before being made obsolete)."
* Added definition dbxref GOC:mah to GO:0016511
* Deleted GO:0016511 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1bf0b9
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0016512 from "Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." to "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor."
* Deleted GO:0016512 --OBO_REL:is_a--> GO:0016511
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 5928b8
* Added comment "This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined."
* Changed definition of GO:0016804 from "Catalysis of the release of a N-terminal proline from a peptide." to "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide."
* Deleted GO:0016804 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1806802
* Changed definition of GO:0016807 from "Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center." to "Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."
* Deleted definition dbxref EC:3.4.18.- from GO:0016807
* Deleted definition dbxref Oxford Dictionary of Biochemistry and Molecular Biology (ISBN:0198506732) from GO:0016807
* Added definition dbxref GOC:mah to GO:0016807
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE to GO:0016807
* Added definition dbxref http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE to GO:0016807
* Deleted GO:0016807 --OBO_REL:is_a--> GO:0008234
* Copied GO:0016807 to GO:0070004 with type OBO_REL:is_a
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0016808 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0016808
* Deleted GO:0016808 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 12c8414
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0016919 from "Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." to "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys."
* Deleted GO:0016919 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1937a2c
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0016921 from "Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." to "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides."
* Deleted GO:0016921 --OBO_REL:is_a--> GO:0008237
* Deleted GO:0016921 --OBO_REL:is_a--> GO:0016920
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 139e4a3
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0016946 from "Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2."
* Deleted GO:0016946 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1d1ca96
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0017026 from "Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." to "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III."
* Deleted GO:0017026 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 4b5767
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0017039 from "Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." to "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides."
* Deleted GO:0017039 --OBO_REL:is_a--> GO:0008239
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 574e38
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0017074 from "Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." to "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln."
* Deleted GO:0017074 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1d0564c
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0017088 from "Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." to "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile."
* Deleted GO:0017088 --OBO_REL:is_a--> GO:0008239
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at d1cbcc
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0017092 from "Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." to "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus."
* Deleted GO:0017092 --OBO_REL:is_a--> GO:0017093
* Deleted GO:0017092 --OBO_REL:is_a--> GO:0008237
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 19ae787
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0017093 from "Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." to "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes."
* Deleted GO:0017093 --OBO_REL:is_a--> GO:0008233
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at d6907d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0017094 from "Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." to "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves."
* Deleted GO:0017094 --OBO_REL:is_a--> GO:0017093
* Deleted GO:0017094 --OBO_REL:is_a--> GO:0008236
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at a821d9
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0017165 from "Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." to "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides."
* Deleted GO:0017165 --OBO_REL:is_a--> GO:0016805
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 466029
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0019131 from "Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." to "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH."
* Deleted GO:0019131 --OBO_REL:is_a--> GO:0008240
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 532a0a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0019132 from "Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." to "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala."
* Deleted GO:0019132 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1ed27ed
* Changed definition of GO:0019828 from "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." to "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process."
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0030019 from "Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." to "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin."
* Deleted GO:0030019 --OBO_REL:is_a--> GO:0004295
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at d87410
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0030271 from "Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." to "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa."
* Deleted GO:0030271 --OBO_REL:is_a--> GO:0004252
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at abf2fb
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0030303 from "Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." to "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak."
* Deleted GO:0030303 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at dd4b71
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0030402 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0030402
* Deleted GO:0030402 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 841758
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0030403 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0030403
* Deleted GO:0030403 --OBO_REL:is_a--> GO:0008133
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 18b58c
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0030404 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0030404
* Deleted GO:0030404 --OBO_REL:is_a--> GO:0008133
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 371926
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0030405 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0030405
* Deleted GO:0030405 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1544c79
* Added comment "This term was made obsolete because it represents a gene product."
* Set definition of GO:0030406 to "OBSOLETE. Was not defined before being made obsolete."
* Added definition dbxref GOC:mah to GO:0030406
* Deleted GO:0030406 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 168b84f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0030601 from "Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." to "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys."
* Deleted GO:0030601 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1c8be2
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0030602 from "Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." to "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein."
* Deleted GO:0030602 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 23bd28
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0030693 from "Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." to "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue."
* Deleted GO:0030693 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 57acf7
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0031079 from "Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." to "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly."
* Deleted GO:0031079 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1c9aaa
* Deleted GO:0031318 --OBO_REL:is_a--> GO:0009593
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0031368 from "Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." to "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid."
* Deleted GO:0031368 --OBO_REL:is_a--> GO:0008322
* Deleted GO:0031368 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1ee2fc8
* Changed definition of GO:0031389 from "A pentameric  protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17,
Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." to "A pentameric  protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p."
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0033264 from "Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." to "OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates."
* Deleted GO:0033264 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 82feb7
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0042029 from "Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." to "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen."
* Deleted GO:0042029 --OBO_REL:is_a--> GO:0004222
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 20c592
* Deleted GO:0042051 --OBO_REL:is_a--> GO:0008594
* Changed comment from "Note that this function was formerly EC:3.4.3.1, EC:3.4.3.2, EC:3.4.3.6, EC:3.4.13.1, EC:3.4.13.2, EC:3.4.13.8, EC:3.4.13.11 and EC:3.4.13.15." to "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0042315 from "Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." to "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids."
* Deleted GO:0042315 --OBO_REL:is_a--> GO:0016805
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 18afc83
* Deleted GO:0042461 --OBO_REL:is_a--> GO:0000904
* Copied GO:0042461 to GO:0048468 with type OBO_REL:is_a
* Deleted GO:0042463 --OBO_REL:is_a--> GO:0008594
* Copied GO:0042463 to GO:0042461 with type OBO_REL:is_a
* Deleted GO:0042478 --OBO_REL:is_a--> GO:0022604
* Copied GO:0042478 to GO:0060284 with type OBO_REL:is_a
* Deleted GO:0042479 --OBO_REL:is_a--> GO:0051130
* Deleted GO:0042480 --OBO_REL:is_a--> GO:0051129
* Changed comment from "Note that this function is distinct from the 'signal peptidases' (see the molecular function term 'signal peptidase activity ; GO:0009003' and its children). Broadly, signal peptidases cleave N-terminal leader sequences from secreted or membrane proteins, thereby creating signal peptides, while signal peptide peptidases cleave the signal peptides themselves." to "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0042499 from "Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." to "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein."
* Deleted GO:0042499 --OBO_REL:is_a--> GO:0042500
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1c8295b
* Changed definition of GO:0042500 from "Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane." to "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane."
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0042576 from "Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." to "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate."
* Deleted GO:0042576 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 134991
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0042708 from "Catalysis of the hydrolysis of elastin." to "OBSOLETE. Catalysis of the hydrolysis of elastin."
* Deleted GO:0042708 --OBO_REL:is_a--> GO:0004175
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 42eb59
* Changed comment from "Note that this function was formerly EC:3.4.19.8." to "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0043275 from "Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." to "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu."
* Deleted GO:0043275 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1695ec4
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0043859 from "Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." to "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides."
* Deleted GO:0043859 --OBO_REL:is_a--> GO:0008236
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at ccb662
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0045024 from "Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." to "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids."
* Deleted GO:0045024 --OBO_REL:is_a--> GO:0008233
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1d9ebba
* Deleted GO:0046113 --OBO_REL:is_a--> GO:0044248
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0046560 from "Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." to "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin."
* Deleted GO:0046560 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 3097d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0046561 from "Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." to "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen."
* Deleted GO:0046561 --OBO_REL:is_a--> GO:0004190
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1642c1f
* Deleted GO:0048493 --OBO_REL:is_a--> GO:0048492
* Copied GO:0048493 to GO:0048494 with type OBO_REL:is_a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0050424 from "Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." to "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups."
* Deleted GO:0050424 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 18cd71f
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0050425 from "Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." to "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid."
* Deleted GO:0050425 --OBO_REL:is_a--> GO:0004181
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 17f632d
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0050426 from "Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." to "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide."
* Deleted GO:0050426 --OBO_REL:is_a--> GO:0008242
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 485eb2
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0051397 from "Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." to "OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain."
* Deleted GO:0051397 --OBO_REL:is_a--> GO:0004177
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1412d9a
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0051398 from "Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." to "OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain."
* Deleted GO:0051398 --OBO_REL:is_a--> GO:0051397
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 190e6b
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0051399 from "Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." to "OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain."
* Deleted GO:0051399 --OBO_REL:is_a--> GO:0051397
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 101c831
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0051404 from "Catalysis of the cleavage of Arg-Xaa bonds." to "OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds."
* Deleted GO:0051404 --OBO_REL:is_a--> GO:0004197
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1fe2c5b
* Added comment "This term was made obsolete because it represents a gene product."
* Changed definition of GO:0051405 from "Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." to "OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds."
* Deleted GO:0051405 --OBO_REL:is_a--> GO:0008133
* org.geneontology.oboedit.datamodel.history.ObsoleteObjectHistoryItem at 1247e8
* Changed definition of GO:0052547 from "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide linkages within proteins." to "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins."
* Changed definition of GO:0052548 from "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide linkages within proteins." to "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins."