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[Midori Harris]

Hi Jim,

I don't think we've yet added a term in this area that was specifically 
motivated by prokaryote-annotation needs. From your brief description, I 
agree that RNA interference is wrong, but would its parent be suitable?

id: GO:0035194
name: RNA-mediated posttranscriptional gene silencing
def: "Any process of gene inactivation (silencing) in which small RNAs 
trigger degradation of mRNA." [PMID:15020054, PMID:15066275, PMID:15066283]

If you need a different term, either as a child of GO:0035194 or placed 
elsewhere, we're happy to add something. It will help immensely if you can 
suggest a name, definition and parent(s).

Midori

On Thu, 9 Aug 2007, Jim Hu wrote:

> Is there an existing process term for RNA-mediated inhibition of translation 
> as it works in prokaryotes?  There are many examples of small RNAs that bind 
> around the translation start site to block initiation (often with the help of 
> hfq) or promote RNA degradation.  I'm seeing these annotated by others to
> 	GO:0016246 ! RNA interference,
>
> but this strikes me as very wrong.  No dsRNA, and the processes are 
> evolutionarily unrelated.
>
> I'm not crazy about
>
> 	GO:0042868 ! antisense RNA metabolic process
>
> for this either.  It also goes into the epigenetic path, which I don't think 
> applies here.
>
> Jim
>
>
> =====================================
> Jim Hu
> Associate Professor
> Dept. of Biochemistry and Biophysics
> 2128 TAMU
> Texas A&M Univ.
> College Station, TX 77843-2128
> 979-862-4054
>