[go]

[David Hill]

I'm no expert in this area, but it sounds like there might be two things 
going on, one is the degradation and the other is the negative 
regulation of translation initiation. Is this all part of the same 
process. I think we should start a SF request for this.

David

Midori Harris wrote:
> Hi Jim,
>
> I don't think we've yet added a term in this area that was 
> specifically motivated by prokaryote-annotation needs. From your brief 
> description, I agree that RNA interference is wrong, but would its 
> parent be suitable?
>
> id: GO:0035194
> name: RNA-mediated posttranscriptional gene silencing
> def: "Any process of gene inactivation (silencing) in which small RNAs 
> trigger degradation of mRNA." [PMID:15020054, PMID:15066275, 
> PMID:15066283]
>
> If you need a different term, either as a child of GO:0035194 or 
> placed elsewhere, we're happy to add something. It will help immensely 
> if you can suggest a name, definition and parent(s).
>
> Midori
>
> On Thu, 9 Aug 2007, Jim Hu wrote:
>
>> Is there an existing process term for RNA-mediated inhibition of 
>> translation as it works in prokaryotes?  There are many examples of 
>> small RNAs that bind around the translation start site to block 
>> initiation (often with the help of hfq) or promote RNA degradation.  
>> I'm seeing these annotated by others to
>>     GO:0016246 ! RNA interference,
>>
>> but this strikes me as very wrong.  No dsRNA, and the processes are 
>> evolutionarily unrelated.
>>
>> I'm not crazy about
>>
>>     GO:0042868 ! antisense RNA metabolic process
>>
>> for this either.  It also goes into the epigenetic path, which I 
>> don't think applies here.
>>
>> Jim
>>
>>
>> =====================================
>> Jim Hu
>> Associate Professor
>> Dept. of Biochemistry and Biophysics
>> 2128 TAMU
>> Texas A&M Univ.
>> College Station, TX 77843-2128
>> 979-862-4054
>>