[go]

[Midori Harris]

Yes, the degradation seems to fit the GO:0035194 df, and we could add a 
more specific child; the other process would go under GO:0045947.

m

On Thu, 9 Aug 2007, David Hill wrote:

> I'm no expert in this area, but it sounds like there might be two things 
> going on, one is the degradation and the other is the negative regulation of 
> translation initiation. Is this all part of the same process. I think we 
> should start a SF request for this.
>
> David
>
> Midori Harris wrote:
>> Hi Jim,
>> 
>> I don't think we've yet added a term in this area that was specifically 
>> motivated by prokaryote-annotation needs. From your brief description, I 
>> agree that RNA interference is wrong, but would its parent be suitable?
>> 
>> id: GO:0035194
>> name: RNA-mediated posttranscriptional gene silencing
>> def: "Any process of gene inactivation (silencing) in which small RNAs 
>> trigger degradation of mRNA." [PMID:15020054, PMID:15066275, PMID:15066283]
>> 
>> If you need a different term, either as a child of GO:0035194 or placed 
>> elsewhere, we're happy to add something. It will help immensely if you can 
>> suggest a name, definition and parent(s).
>> 
>> Midori
>> 
>> On Thu, 9 Aug 2007, Jim Hu wrote:
>> 
>>> Is there an existing process term for RNA-mediated inhibition of 
>>> translation as it works in prokaryotes?  There are many examples of small 
>>> RNAs that bind around the translation start site to block initiation 
>>> (often with the help of hfq) or promote RNA degradation.  I'm seeing these 
>>> annotated by others to
>>>     GO:0016246 ! RNA interference,
>>> 
>>> but this strikes me as very wrong.  No dsRNA, and the processes are 
>>> evolutionarily unrelated.
>>> 
>>> I'm not crazy about
>>>
>>>     GO:0042868 ! antisense RNA metabolic process
>>> 
>>> for this either.  It also goes into the epigenetic path, which I don't 
>>> think applies here.
>>> 
>>> Jim
>>> 
>>> 
>>> =====================================
>>> Jim Hu
>>> Associate Professor
>>> Dept. of Biochemistry and Biophysics
>>> 2128 TAMU
>>> Texas A&M Univ.
>>> College Station, TX 77843-2128
>>> 979-862-4054
>>> 
>