[go] 'regulation of gene expression'

[E Dimmer]

Hi,

There is a large number of terms in GO which deserve more information 
regarding the 'target' of its gene product's activity, for instance:
-- negative regulation of ubiquitination
-- protein kinase activity
-- regulation of DNA binding
-- regulation of phosphorylation
-for all of these examples I have information on the specific target of 
a protein's action.

While I strongly feel that this target information should be captured -- 
is the 'with' the right place? We seem to have tried to be very strict 
on the contents of the 'with', so the type of value used is closely 
related to the type of evidence code applied in the annotation. I'm not 
sure that regulation of expression be an exception to this...

Emily


Pankaj Jaiswal wrote:
>
>
> Harold Drabkin wrote:
>
>> Perhaps if used, one needs to restrict the evidence code used with it 
>> to IEP and perhaps also allow a With field dbx ref for a gene_id if 
>> known or suspected
>>
>
> With field filling should be 'a must' because the regulation of 
> expression is always in context to another gene (product). However the 
> code can also be IPI, IGI, IMP besides IEP.
>
> Pankaj


-- 
 ************************************
    Emily Dimmer
    GOA Coordinator
    EMBL-EBI
    Wellcome Trust Genome Campus
    Hinxton
    Cambridge CB10 1SD, U.K.
    Tel:     +44 1223 494654
    Fax:    +44 1223 494468
    email:  edimmer at ebi.ac.uk
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