[go] 'regulation of gene expression'

[David Hill]

We capture this info in our structure notes. I think it will be very 
valuable information.

David

E Dimmer wrote:
> Hi,
>
> There is a large number of terms in GO which deserve more information 
> regarding the 'target' of its gene product's activity, for instance:
> -- negative regulation of ubiquitination
> -- protein kinase activity
> -- regulation of DNA binding
> -- regulation of phosphorylation
> -for all of these examples I have information on the specific target 
> of a protein's action.
>
> While I strongly feel that this target information should be captured 
> -- is the 'with' the right place? We seem to have tried to be very 
> strict on the contents of the 'with', so the type of value used is 
> closely related to the type of evidence code applied in the 
> annotation. I'm not sure that regulation of expression be an exception 
> to this...
>
> Emily
>
>
> Pankaj Jaiswal wrote:
>>
>>
>> Harold Drabkin wrote:
>>
>>> Perhaps if used, one needs to restrict the evidence code used with 
>>> it to IEP and perhaps also allow a With field dbx ref for a gene_id 
>>> if known or suspected
>>>
>>
>> With field filling should be 'a must' because the regulation of 
>> expression is always in context to another gene (product). However 
>> the code can also be IPI, IGI, IMP besides IEP.
>>
>> Pankaj
>
>