[go] Putting method/program names into the with field for ISS
Ben Hitz
hitz at genome.Stanford.EDU
Thu Sep 20 08:37:03 PDT 2007
>
> I guess my question is, what excludes tRNA scan, and TMM predictors
> from being RCA?
> and, if it is because they are sequence-based, will we need to
> revisit this all over again when we have other predictions which
> don't fit RCA or ISS in future?
If I understand Karen's position - it's that these methods rely more
or less exclusively on "sequence and or structural" information.
And yet (IMHO), because they do not match a specific entity and/or
family subfamily, they are clearly different types of "methods".
A possibly resolution might be to redefine ISS (and possibly rename)
to specifically mean "homology based methods which match to a
specific sequence entity or family". This language has to be a bit
vague to allow for homology assignments for RNAs.
tRNA scan /TMHMM would fall under RCA, and perhaps we should also
adopt Karen's new code for "mixed computational analysis" for more
integrative statistical methods.
Ben
--
Ben Hitz
Senior Scientific Programmer ** Saccharomyces Genome Database ** GO
Consortium
Stanford University ** hitz at genome.stanford.edu
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