[go] concern about 'tricarboxylic acid cycle intermediate metabolic process' GO:0006100

Midori Harris midori at ebi.ac.uk
Thu Feb 21 08:15:01 PST 2008


Hi all,

In SF 1894620, I corrected a true path violation for 'TCA cycle' 
(GO:0006099) that Peter D'Eustachio noticed. That work also brought 
'tricarboxylic acid cycle intermediate metabolic process' (GO:0006100) to 
our attention. It has the same parent -- 'cellular carbohydrate metabolic 
process' (GO:0044262) -- that caused the TPV for TCA cycle, but has no 
other parents. Peter and I reached the conclusion that GO:0006100 serves 
merely as a  grouping term from "metabolism of molecules that make an 
appearance in the TCA cycle", and that, while not entirely nonsense, 
having 'cycle intermediates' process terms is a really rich sources of 
tpv's.

We therefore suggest that the safest course of action is to make 
GO:0006100 obsolete. Annotations can be transferred to TCA cycle or to one 
of the children of GO:0006100.

Before I start the procedure to make GO:0006100 obsolete, can anyone 
recall or think of any reasons to keep the term? If we do, I think it 
would have to go directly under cellular metabolic process.

https://sourceforge.net/tracker/index.php?func=detail&aid=1894620&group_id=36855&atid=440764

Midori



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