[Go] Muscle Biology Content Meeting Publication

[Chris Mungall]

hmm, seem to have lost my edits.. ah well

> Our revised ontology structure should facilitate the interpretation  
> of high-throughput experiments (e.g. gene expression microarrays)  
> in the area of muscle science and muscular disease. Such studies  
> yield a very large number of data points and this makes it a  
> challenge to determine which genes specifically contribute to a  
> disease phenotype [17]. However the use of GO ontologies and  
> annotations within GO-related statistical analysis tools [18]  
> should greatly simplify this analysis .


So I think this is very true, but what would make this highly  
compelling would be some examples. Perhaps:

* A reference genome gene that is muscle related, graphs before and  
after the ontology change
* Some actual high throughput experimental results, enriched, before  
and after

Of course changes will only be reflected in the upper level grouping  
of results, as people may not have time to annotate to the newer more  
specific terms

I can help with this, given a gene list.

On Mar 19, 2008, at 7:34 AM, Midori Harris wrote:

> Hi,
>
> The manuscript looks well organized and summarizes the changes  
> nicely. I've made some comments and suggestions in the attached  
> version.
>
> m
>
> On Fri, 14 Mar 2008, Jennifer Deegan (nee Clark) wrote:
>
>> Hi,
>>
>> Erika Feltrin and I have written a paper about the Muscle Biology
>> Content Meeting, to be sent to BMC Medical Genomics.
>> We would really appreciate any comments on the manuscript:
>> http://www.ebi.ac.uk/~jdeegan/stored/musclepaper/ 
>> muscle_paper_ver_1.doc
>>
>> We are also offering a small prize for anyone who can come up with a
>> suitably cheezy title, including a bad pun on the word 'GO'.
>>
>> Thanks,
>>
>> Jen
>>
>>
>> <muscle_paper_ver_1a.doc>
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