[Go] Advice on adding an enzyme function

Jane Lomax jane at ebi.ac.uk
Wed May 21 03:24:25 PDT 2008


Hi - do we have any guidelines anywhere for when to add an enzyme 
function term or not? I had a look on the wiki and in the documentation 
and couldn't see anything. If not, perhaps we should add something - it 
seems that there have been quite a few discussions in this area and 
might be good to capture it all somewhere.

Anyhow, my dilemma is this - we have a term 'diamine N-acetyltransferase 
activity ;  GO:0004145' which has EC 2.3.1.57. The EC is based on the 
eukaryotic enzyme, and the reaction catalysed is: acetyl-CoA + an 
alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. Several different 
substrates (i.e. alkane-alpha,omega-diamines) are acted upon.

The equivalent prokaryotic enzyme has essentially the same reaction, 
*but* acts on a different range of alkane-alpha,omega-diamine substrates.

So should I add a new term for the prokaryotic function or not?

thanks,

Jane


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