[Go] Advice on adding an enzyme function
Jane Lomax
jane at ebi.ac.uk
Wed May 21 03:24:25 PDT 2008
Hi - do we have any guidelines anywhere for when to add an enzyme
function term or not? I had a look on the wiki and in the documentation
and couldn't see anything. If not, perhaps we should add something - it
seems that there have been quite a few discussions in this area and
might be good to capture it all somewhere.
Anyhow, my dilemma is this - we have a term 'diamine N-acetyltransferase
activity ; GO:0004145' which has EC 2.3.1.57. The EC is based on the
eukaryotic enzyme, and the reaction catalysed is: acetyl-CoA + an
alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. Several different
substrates (i.e. alkane-alpha,omega-diamines) are acted upon.
The equivalent prokaryotic enzyme has essentially the same reaction,
*but* acts on a different range of alkane-alpha,omega-diamine substrates.
So should I add a new term for the prokaryotic function or not?
thanks,
Jane
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