[Go] Alert: proposal to obsolete two molecular function terms that impacts existing annotations

Midori Harris midori at ebi.ac.uk
Mon Mar 16 08:11:28 PDT 2009


Dear GO,

The proposal has been made to obsolete

   apolipoprotein E receptor activity ; GO:0030227
   apolipoprotein E receptor binding ; GO:0050749

Annotations to these terms exist as listed below:

   gene_association.goa_cow.gz
   GO ID	IEA	non-IEA	total
   GO:0050749	1	0	1

   gene_association.goa_human.gz
   GO ID	IEA	non-IEA	total
   GO:0030227	0	1	1

   gene_association.goa_uniprot.gz
   GO ID	IEA	non-IEA	total
   GO:0050749	5	0	5

   gene_association.rgd.gz
   GO ID	IEA	non-IEA	total
   GO:0030227	0	1	1
   GO:0050749	1	0	1

The reason for obsoleting these terms is that no known receptor binds 
apolipoprotein E; instead, receptors bind holo-lipoprotein E 
(apolipoprotein E + bound lipid).

Annotations should be transferred to VLDL receptor terms:

   very-low-density lipoprotein receptor activity ; GO:0030229
   very-low-density lipoprotein receptor binding ; GO:0070326

These terms are not in any GO slim or subset maintained in the GO .obo
files, and are not used in any external mappings.

SourceForge link:
https://sourceforge.net/tracker/index.php?func=detail&aid=2686128&group_id=36855&atid=440764

Comment period ends on March 31, 2009.

*** Unless objections are received by March 31,
      we will assume that you agree to this change. ***

Thanks,
Midori
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