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<TITLE>Binding call at 11 EDT today</TITLE>
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<FONT FACE="Calibri, Verdana, Helvetica, Arial"><SPAN STYLE='font-size:11pt'>Hi,<BR>
I’ll be a little late today, but will call in at the end. Here are some ‘go-top’ type thoughts on this, but this also incorporates the GO@MGI specific thoughts as well. I look forward to a considerate discussion.<BR>
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Judy<BR>
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We...<BR>
</SPAN></FONT><OL><LI><FONT FACE="Calibri, Verdana, Helvetica, Arial"><SPAN STYLE='font-size:11pt'>support everyone who have sought to clarify the binding discussion; update documentation,
</SPAN></FONT><LI><FONT FACE="Calibri, Verdana, Helvetica, Arial"><SPAN STYLE='font-size:11pt'>recognize that the binding discussion is confounded by complexity of assays and kinetics of ‘binding’ studies,
</SPAN></FONT><LI><FONT FACE="Calibri, Verdana, Helvetica, Arial"><SPAN STYLE='font-size:11pt'>commit to ‘annotating to the experiment’ meaning trying to capture the specifics as much as feasible; use the binding term if the experiment shows binding, don’t use if experiment shows catalysis but not specific binding the gene product,
</SPAN></FONT><LI><FONT FACE="Calibri, Verdana, Helvetica, Arial"><SPAN STYLE='font-size:11pt'>reaffirm our commitment to provide practical and useful data to enhance the work of biologists,
</SPAN></FONT><LI><FONT FACE="Calibri, Verdana, Helvetica, Arial"><SPAN STYLE='font-size:11pt'>remember that ‘consistency’ is a principle, not a rule; there will be exceptions: here what is needed is a statement of standard, such as provided in ‘3’. The goal is to have ‘correct’ annotations, not that everyone should have the same annotation,
</SPAN></FONT><LI><FONT FACE="Calibri, Verdana, Helvetica, Arial"><SPAN STYLE='font-size:11pt'>consider that if existing annotations (~8,000?) involving binding terms are not wrong, then we should strongly consider keeping them,
</SPAN></FONT><LI><FONT FACE="Calibri, Verdana, Helvetica, Arial"><SPAN STYLE='font-size:11pt'>and, confirm that any global change will need approval by GO-top
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