<html><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; ">Hi Judy<div><br></div><div>thanks for these comments. I will add them to the conference call wiki</div><div><br></div><div>Ruth</div><div><br><div><div>On 11 Jun 2009, at 15:35, Judith Blake wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite"><div> <font face="Calibri, Verdana, Helvetica, Arial"><span style="font-size:11pt">Hi,<br> I’ll be a little late today, but will call in at the end. Here are some ‘go-top’ type thoughts on this, but this also incorporates the GO@MGI specific thoughts as well. I look forward to a considerate discussion.<br> <br> Judy<br> <br> We...<br> </span></font><ol><li><font face="Calibri, Verdana, Helvetica, Arial"><span style="font-size:11pt">support everyone who have sought to clarify the binding discussion; update documentation, </span></font></li><li><font face="Calibri, Verdana, Helvetica, Arial"><span style="font-size:11pt">recognize that the binding discussion is confounded by complexity of assays and kinetics of ‘binding’ studies, </span></font></li><li><font face="Calibri, Verdana, Helvetica, Arial"><span style="font-size:11pt">commit to ‘annotating to the experiment’ meaning trying to capture the specifics as much as feasible; use the binding term if the experiment shows binding, don’t use if experiment shows catalysis but not specific binding the gene product, </span></font></li><li><font face="Calibri, Verdana, Helvetica, Arial"><span style="font-size:11pt">reaffirm our commitment to provide practical and useful data to enhance the work of biologists, </span></font></li><li><font face="Calibri, Verdana, Helvetica, Arial"><span style="font-size:11pt">remember that ‘consistency’ is a principle, not a rule; there will be exceptions: here what is needed is a statement of standard, such as provided in ‘3’. The goal is to have ‘correct’ annotations, not that everyone should have the same annotation, </span></font></li><li><font face="Calibri, Verdana, Helvetica, Arial"><span style="font-size:11pt">consider that if existing annotations (~8,000?) involving binding terms are not wrong, then we should strongly consider keeping them, </span></font></li><li><font face="Calibri, Verdana, Helvetica, Arial"><span style="font-size:11pt">and, confirm that any global change will need approval by GO-top </span></font></li><li></li></ol> </div> </blockquote></div><br></div></body></html>