[gofriends] [Reactome-announce] Reactome version 24 release today

[Peter D'Eustachio]

Version 24 of the Reactome Knowledgebase has been released and is accessible at http://www.reactome.org.

Reactome is a curated knowledgebase developed and maintained by the Reactome Knowledgebase team (Lincoln Stein's group at CSHL, Ewan Birney's group at the European Bioinformatics Institute, and Peter D'Eustachio's group at NYU). Reactome covers human biological processes ranging from basic pathways of metabolism to complex events such as hormonal signaling and apoptosis. The information in Reactome is provided by expert bench biologists, and edited and managed as a relational database by the Reactome staff. New material is peer-reviewed and revised as necessary before publication to the web. Reactome entries are linked to corresponding ones in NCBI, Entrez Gene, RefSeq, OMIM, Ensembl genome annotations, HapMap, UCSC Genome Browser, KEGG, ChEBI and Gene Ontology (GO).

The web interface allows users to view the curated annotations of human biological processes and orthology-based electronic inferences from these annotations for 22 other species.

New additions to curated content include the pathway topics: Signaling by VEGF, Metabolism of nitric oxide, and MicroRNA biogenesis, and new modules added to existing pathways: Cleavage reactions (Apoptosis), Generic transcription pathway (Gene expression), Tie2 and PECAM events (Hemostasis), TCR cascade (Immune signaling), Pyruvate Decarboxylase regulation (Energy metabolism), COP II mediated events (Membrane Trafficking), Hypusine synthesis (Post translational modifications), PLC-gamma and Grb2 mediated downstream events (EGFR signaling). This material was generated in collaboration with K Schulze-Osthoff, and L Castognoli (authors), and S Ranganathan, LP Freedman, J Trowsdale, J Lippincott-Schwartz, G Enikolopov, F Karginov, GJ Hannon, CH Heldin, and L Claesson-Welsh (reviewers).

A new pathway visualization tool (beta version) is available with this release. Please try it, and send us feedback.

Pathway annotations from Reactome are now incorporated into the Pathway Interaction Database (PID), a collaborative project between the US National Cancer Institute and Nature Publishing Group. Access to 703 Reactome curated pathways and a primer for using Reactome data are available from PID's website at http://pid.nci.nih.gov/

Updated release statistics and the Editorial Calendar are available. Data download including database dumps and protein-protein interaction datasets are available from the download page on the website. Reactome data can be exported in SMBL, Protégé, and BioPAX level 2 formats. Like everything in Reactome, these downloaded and exported materials can be reused. Users can subscribe to Reactome announcement list from the webpage at http://mail.reactome.org/mailman/listinfo/reactome-announce.

Reactome is seeking expert help for the curation of new modules. The Reactome knowledgebase relies on collaborations with research biologists to construct expert consensus views of key biological processes, and to integrate these with other processes already in Reactome. We are seeking new author-collaborators. If you're interested, or would like more information about our data acquisition process, please contact us at editorial at reactome.org.

For questions and comments please reply to this message or write to help at reactome.org.



-The Reactome team
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