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<p>Version 29 of the Reactome Knowledgebase has been released at
<font color="#000080"><span lang="zxx"><u><a class="western" href="http://www.reactome.org/">http://www.reactome.org</a></u></span></font>.
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<p>Reactome is a free, online, open-source, curated resource of core
pathways and reactions in human biology. Information is authored by
expert biological researchers, maintained by the Reactome editorial
staff and cross-referenced to the NCBI Entrez Gene, Ensembl and
UniProt databases, the UCSC and HapMap Genome Browsers, the KEGG and
ChEBI small molecule databases, PubMed, and the Gene Ontology (GO).</p>
<p><b>New content.</b> As part of a project to annotate the general
process of cell motility and its involvement in key biological
processes, Version 29 introduces a new topic, Axon guidance, with
material now available for NCAM signaling in neurite outgrowth.
Pathway topics updated with new curated events in this release
include: Synaptic transmission (Glutamate Binding, Activation of AMPA
Receptors, and Synaptic Plasticity), DNA Repair (regulation of FANCD2
and FANCI activity in the Fanconi Anemia pathway), and pathways whose
dysfunction plays a major role in the development of diabetes
(Regulation of insulin secretion and Unfolded protein response). With
the annotation of G-coupled protein receptors (GPCRs) for
eicosanoids, leukotrienes, nucleotide-like (purinergic) molecules,
LPA and lysosphingolipids, opsins, secretins, and GABA and related
molecules (class C/3 receptors), our annotation of interactions
between GPCRs and their ligands is essentially complete. The Telomere
Maintenance pathway has been revised in this release. Updated release
statistics are available.</p>
<p><b>Data access. </b>The web interface allows users to view the
curated annotations of human biological processes and orthology-based
electronic inferences from these annotations for 22 other species.
Data downloads including database dumps and protein-protein
interaction datasets are available from the download page on the
website. Reactome data can be exported in SMBL, Protégé, and BioPAX
level 2 formats. Like everything in Reactome, these downloaded and
exported materials can be modified and reused freely. Users can
subscribe to Reactome announcement list from the webpage at
<font color="#000080"><span lang="zxx"><u><a class="western" href="http://mail.reactome.org/mailman/listinfo/reactome-announce">http://mail.reactome.org/mailman/listinfo/reactome-announce</a></u></span></font>.</p>
<p>Pathway annotations from Reactome are now incorporated into the
Pathway Interaction Database (PID), a collaborative project between
the US National Cancer Institute and Nature Publishing Group. Access
to 703 Reactome curated pathways and a primer for using Reactome data
are available from PID's website at <font color="#000080"><span lang="zxx"><u><a class="western" href="http://pid.nci.nih.gov/">http://pid.nci.nih.gov/</a></u></span></font>.</p>
<p>The pathway visualization tool (beta version) is available on the
website from the Tools menu. A Search tool with features of popular
search engines has been implemented. Please try these tools and let
us know your comments (<a href="mailto:help@reactome.org">help@reactome.org</a>).</p>
<p><b>Work in progress.</b> Reactome is seeking expert help for the
curation of new modules – ones now underway are listed in our
editorial calendar.. The Reactome knowledgebase relies on
collaborations with research biologists to construct expert consensus
views of key biological processes, and to integrate these with other
processes already in Reactome. We are seeking new
author-collaborators. If you're interested, or would like more
information about our data acquisition process, please contact us at
<a href="mailto:editorial@reactome.org">editorial@reactome.org</a>.</p>
<p>A list of projects underway to develop Reactome-like pathway
databases for non-human model organisms with contact information is
available from <font color="#000080"><span lang="zxx"><u><a class="western" href="http://www.reactome.org/other_reactomes.html">http://www.reactome.org/other_reactomes.html</a></u></span></font>.</p>
<br>
<p>-The Reactome team</p>
<p><br><br>
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