[immunology] IFN induction to GO mapping

[Alexander Diehl]

Evelyn,

The fact that their definition includes "regulation of proliferation of 
normal and malignant cells," makes me a bit reluctant to make this 
mapping.  Sure interferons themselves have various roles in the immune 
response, but the definition provided here implies other roles which may 
go beyond the immune response.  We would not annotate to "immune 
response" a gene simply because its expression level changes in a 
microarray experiment in response to a cytokine with a known role in the 
immune response, and this seems to be a similar type of proposition.

I oppose this mapping.

Thanks,

Alex


camon at ebi.ac.uk wrote:
> Hi
>
> UniProtKB have a keyword 'Interferon induction' which they assign to
> proteins that are induced by interferon. They are asking if they can map
> this to the GO term 'immune response'.
>
> Suggestions? Its a bit of a strange kw.
>
> Here is the DEFINITION:
>
> ID   Interferon induction.
> AC   KW-0402
> DE   Protein induced by interferon(s). Interferons are a class of cytokines
> DE   which mediate, by binding to specific cell-surface receptors, a broad
> DE   range of activities such as resistance to viral infection, modulation
> DE   of the immune response and regulation of proliferation of normal and
> DE   malignant cells.
> SY   IFN induction.
>
> and here are the proteins with that annotation:
>
> http://ca.expasy.org/cgi-bin/get-entries?KW=Interferon%20induction
>
> Evelyn
>
>
>   


-- 
Alexander Diehl, Ph.D.
Senior Scientific Curator
Mouse Genome Informatics
The Jackson Laboratory
600 Main Street
Bar Harbor, ME  04609

email:  adiehl at informatics.jax.org
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