[immunology] IFN induction to GO mapping

[camon at ebi.ac.uk]

Thanks Alex for your prompt response,

I also think it is a safest option not to map,

Evelyn


> Evelyn,
>
> The fact that their definition includes "regulation of proliferation of
> normal and malignant cells," makes me a bit reluctant to make this
> mapping.  Sure interferons themselves have various roles in the immune
> response, but the definition provided here implies other roles which may
> go beyond the immune response.  We would not annotate to "immune
> response" a gene simply because its expression level changes in a
> microarray experiment in response to a cytokine with a known role in the
> immune response, and this seems to be a similar type of proposition.
>
> I oppose this mapping.
>
> Thanks,
>
> Alex
>
>
> camon at ebi.ac.uk wrote:
>> Hi
>>
>> UniProtKB have a keyword 'Interferon induction' which they assign to
>> proteins that are induced by interferon. They are asking if they can map
>> this to the GO term 'immune response'.
>>
>> Suggestions? Its a bit of a strange kw.
>>
>> Here is the DEFINITION:
>>
>> ID   Interferon induction.
>> AC   KW-0402
>> DE   Protein induced by interferon(s). Interferons are a class of
>> cytokines
>> DE   which mediate, by binding to specific cell-surface receptors, a
>> broad
>> DE   range of activities such as resistance to viral infection,
>> modulation
>> DE   of the immune response and regulation of proliferation of normal
>> and
>> DE   malignant cells.
>> SY   IFN induction.
>>
>> and here are the proteins with that annotation:
>>
>> http://ca.expasy.org/cgi-bin/get-entries?KW=Interferon%20induction
>>
>> Evelyn
>>
>>
>>
>
>
> --
> Alexander Diehl, Ph.D.
> Senior Scientific Curator
> Mouse Genome Informatics
> The Jackson Laboratory
> 600 Main Street
> Bar Harbor, ME  04609
>
> email:  adiehl at informatics.jax.org
> work:  +1 (207) 288-6427
> fax:  +1 (207) 288-6131
>