axon regeneration as part of differentiation?

[erika at cribi.unipd.it]

Hi Doug, 
I agree with you about axon regeneration.
I think that this mechanism is in response to injury.
Regeneration requires a multistep processes. First, the injured neuron must
survive, and then the damaged axon must extend its cut processes to is original
neuronal targets.Once, contact is made, the axon needs to be remyelinated and
functional synapses need to form on the surface of the targeted neurons.
I think that it would be possible to talk about to aspects of regeneration:
functional regeneration and morphological regeneration.
The last one is about the regeneration of the tipical structure of a neuron in
the damaged tissue.
The first pertains to the re-establishment of neuronal function (functional
synaptic connection and re-myelination.
What do you think about it?

Erika


Quoting Doug Howe <dhowe at cs.uoregon.edu>:

> I wanted to see if anyone else in the Neuro interest group thought there
> 
> was an issue here before I posted a SF tracker item on it. 
> 
> The term GO:0031103 'axon regeneration' has 'neuron morphogenesis during
> 
> differentiation' in it's path to root. This means that the process of 
> 'axon regeneration' in GO is implicitly restricted to occur during 
> neuron differentiation.   This doesn't seem correct to me.  It seems to
> 
> me that 'axon regeneration' is the extenstion of an axon by a mature 
> neuron (ie not a differentiating neuron) after loss of the axon for some
> 
> reason.  This process doesn't involve de-differentiation and 
> re-differentiation of the neuron.
> 
>  Does anyone else see it that way?
> 
> I'm not in tune with the current biology on this, so I could be
> incorrect.
> 
> -Doug
> 
> -- 
> * * * * * * * * * * * * * * * *
> Doug Howe, Ph.D.
> ZFIN Scientific Curator
> Zebrafish Information Network
> 5291 University of Oregon
> Eugene, OR 97403-5291
> 
> Phone: (541) 346-5733
> * * * * * * * * * * * * * * * *
> 



Erika Feltrin, PhD Student
Bioinformatics Lab c/o CRIBI
Padua University
via U. Bassi, 58/b 35131

erika at cribi.unipd.it
+ 39.049.827.6165
+ 39.049.827.6159