[Ontology-editors] forward and reverse transcription

[Midori Harris]

Wait, I'm confused now about what you guys favor. RNA-dependent synthesis 
of RNA isn't transcription at all; it's RNA replication.

Transcription is the interconversion of DNA and RNA by synthesizing one on 
a template made of the other. Synthesis of RNA on a DNA template is 
considered "forward" because it's by far the more common direction.

m

On Mon, 1 Dec 2008, David Hill wrote:

> I agree with Harold.  Reverse transcription refers to the process of 
> reversing the transcription process, not a type of transcription.
>
> Harold Drabkin wrote:
>> Hmm, from  the def of 64101, the term name really doesn't fit, since to me, 
>> RNA -dependent transcription would be a process whereby an RNA template is 
>> transcribed to create another RNA molecule. As it's defined, it is 
>> "reverse" transcription.
>> Based on the def, I would vote to merge them.
>> Posted to SF also
>> 
>> 
>> Midori Harris wrote:
>>> Hi,
>>> 
>>> A couple of questions have come up in SF 2354289:
>>> 
>>> 1. Should these terms be merged?
>>>
>>>   id: GO:0006278
>>>   name: RNA-dependent DNA replication
>>>   def: "The process whereby new strands of DNA are synthesized, using RNA
>>>   as a template for RNA-dependent DNA polymerases (e.g. reverse
>>>   transcriptase) that synthesize the new strands."
>>>
>>>   id: GO:0006410
>>>   name: transcription, RNA-dependent
>>>   namespace: biological_process
>>>   def: "The synthesis of DNA on a template of RNA."
>>> 
>>> 2. Should reverse transcription be considered part of gene expression (at 
>>> present it is, by transitivity, but if it shouldn't be, it's easy to 
>>> change)?
>>> 
>>> Comments here or on the SF item much appreciated.
>>> 
>>> https://sourceforge.net/tracker/index.php?func=detail&aid=2354289&group_id=36855&atid=440764 
>>> 
>>> Midori