[Ontology-editors] histone modifications - process or function?

Jane Lomax jane at ebi.ac.uk
Tue Dec 16 03:55:17 PST 2008


Hi - I've got a small mapping to do (~50 terms), most of which are 
histone modifications, e.g.

Histone 2B Acetylation
Histone 2B Acetylation  K5
Histone 2B Acetylation  K12

We have terms for specific histone modifications in both function e.g. 
'histone lysine N-acetyltransferase activity (H3-K56 specific)' and 
process e.g. 'histone H3-R17 methylation'.

So I'm not sure whether to add the new terms for the mapping to process 
or function. I'm leaning towards process.

And more generally, there are a lot of cases like this where we have a 
chemical reaction that is essentially duplicated in both process and 
function (e.g. phosphorylation v/s kinase). We'll be able to make 
function-process links between these terms soon - so does it really 
matter that we have this duplication?

Jane

-- 
Dr Jane Lomax
GO Editorial Office
EMBL-EBI
Wellcome Trust Genome Campus
Hinxton
Cambridgeshire, UK
CB10 1SD

p: +44 1223 492516
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