[Ontology-editors] histone modifications - process or function?

[Midori Harris]

Yeah, there are tons in the protein/amino acid modification area. David 
and I have just been thinking (hoping?) the f-p links would help make 
sense of it all.

For the mapping, process sounds reasonable; it's just possible that 
something other than the catalytic gp could also be involved in the 
modification (yes, I'm hand-waving!).
m

On Tue, 16 Dec 2008, Jane Lomax wrote:

> Hi - I've got a small mapping to do (~50 terms), most of which are histone 
> modifications, e.g.
>
> Histone 2B Acetylation
> Histone 2B Acetylation  K5
> Histone 2B Acetylation  K12
>
> We have terms for specific histone modifications in both function e.g. 
> 'histone lysine N-acetyltransferase activity (H3-K56 specific)' and process 
> e.g. 'histone H3-R17 methylation'.
>
> So I'm not sure whether to add the new terms for the mapping to process or 
> function. I'm leaning towards process.
>
> And more generally, there are a lot of cases like this where we have a 
> chemical reaction that is essentially duplicated in both process and function 
> (e.g. phosphorylation v/s kinase). We'll be able to make function-process 
> links between these terms soon - so does it really matter that we have this 
> duplication?
>
> Jane
>
>