[Ontology-editors] stem cells [was Re: help wanted getting CL and GO consistent]

[Chris Mungall]

What about these:

> ** GO:0048103 somatic stem cell division **
> GO:0055057 neuroblast division

> ** GO:0048864 stem cell development **
> GO:0014019 neuroblast development

> ** GO:0048863 stem cell differentiation **
> GO:0010054 trichoblast differentiation
> GO:0010055 atrichoblast differentiation
> GO:0014016 neuroblast differentiation

I would have thought the neuroblast cases would be straightforward  
examples of CL being right and GO needing to add the 3 links above.

However, fly_anatomy has neuroblast as a subtype of precursor cell and  
sibling of stem cell (both undefined):

     is_a FBbt:00007008 ! precursor cell
       is_a FBbt:00001666 ! cardioblast
       is_a FBbt:00004860 ! germ cell
       is_a FBbt:00004874 ! oogonial cell
       is_a FBbt:00004947 ! acroblast
       is_a FBbt:00004994 ! epidermoblast
       is_a FBbt:00005041 ! tracheal precursor cell
       is_a FBbt:00005083 ! myoblast
       is_a FBbt:00005145 ! glioblast
       is_a FBbt:00005146 ! neuroblast ***  [DEF: "A neural stem cell  
which delaminates from the ectoderm and which buds off new ganglion  
mother cells during the course of development."]
       is_a FBbt:00005149 ! ganglion mother cell
       is_a FBbt:00005220 ! hemangioblast [DEF: "A cell type of the  
cardiac mesoderm which gives rise to a subpopulation of the  
cardioblasts and pericardial cells."]
       is_a FBbt:00005605 ! imaginal tracheal precursor
       is_a FBbt:00007014 ! stem cell
       is_a FBbt:00007021 ! larval oenocyte precursor [DEF: "Larval  
oenocyte precursors first become apparent during stage 11 when a small  
group of cells encircling each chordotonal organ precursor cell C1  
become sickle shaped, making a

ZFA is perfectly aligned with CL:

    is_a ZFA:0009000 ! cell
     is_a ZFA:0009307 ! somatic stem cell
      is_a ZFA:0009020 ! multi fate stem cell
       is_a ZFA:0009019 ! neuronal stem cell
        is_a ZFA:0009011 ! neuroblast ***

I'd like to get a plant person involved to make sure the  
(a)trichoblast classification in CL is improved (currently these are  
both animal and plant cells!)

I suggest the following:

- GO adds the 3 proposed neuroblast BP links
- I will transfer the embedded GO definition of somatic stem cell to  
CL (where it is currently undefined).
	"a stem cell that can give rise to cell types of the body other than  
those of the germ-line" OR
	"undifferentiated cells in the embryo or adult which can undergo  
unlimited division and give rise to cell types of the body other than  
those of the germ-line"