[Ontology-editors] [Transport] calcium ion transport question

[Midori Harris]

On Fri, 6 Feb 2009, Chris Mungall wrote:

>
> On Feb 6, 2009, at 6:52 AM, Midori Harris wrote:
>
>> Actually, we already have a term for 'calcium ion transport into cytosol' 
>> (GO:0060402), which does not have the negative regulation of sequestering 
>> parentage that GO:0051209 has. So I'll make GO:0060402 an additional parent 
>> of GO:0051209. That's consistent with everything here and in the ontology.
>
> is_a parent?
>
> That means GO:0060402 will have an only is_a child, which invites the 
> question, what kinds of GO:0060402 ! calcium ion transport into cytosol are 
> not kinds of GO:0051209 ! release of sequestered calcium ion into cytosol?

GO:0060402 would cover transport of calcium ions into the cytosol from 
anywhere; it isn't restricted to release from organellar stores (and so 
also doesn't have the restriction that GO:0051209 does of representing 
negative regulation of sequestration).

Although we don't yet have any siblings of GO:0051209, there appears to be 
at least some sort of calcium transport from outside the cell to the 
cytosol, and between the nucleus and the cytosol, for which we may 
eventually want to add one or more terms. E.g. 
http://jeb.biologists.org/cgi/content/abstract/184/1/17, PMID:9672757.

> Also, shouldn't we make GO:0060402 an is_a child of
> GO:0007204 ! elevation of cytosolic calcium ion concentration
> ?

done
m

>
>> 
>> m
>> 
[snip]