[Ontology-editors] DASH complex - two part_of parents

Midori Harris midori at ebi.ac.uk
Mon Feb 23 04:46:08 PST 2009


Hi,

This is just to record that Val and I have looked at the literature on the 
DASH complex (GO:0042729), and agreed that it's OK for it to have two 
part_of parents for now.

Background: the DASH complex term was originally added with two part_of 
parents, GO:0000778 condensed nuclear chromosome kinetochore and 
GO:0005828 kinetochore microtubule. It was duly flagged by Chris' QC 
report, and at a meeting involving Jane, David and me, Jane created two
child terms to avoid true path violations. After that work we had:

   DASH complex GO:0042729
   [i] kinetochore-associated DASH complex GO:0043926
   [i] microtubule-associated DASH complex GO:0043925

   condensed nuclear chromosome kinetochore
   [p] kinetochore-associated DASH complex GO:0043926

   kinetochore microtubule
   [p] microtubule-associated DASH complex GO:0043925

But Val and I confirmed that, as far as is known in the field, every DASH 
complex that forms is part of a kinetochore and associated with 
kinetochore microtubules. I think using a different relationship type, 
perhaps associated_with or connected_to or adjacent_to, between DASH 
complex and kinetochore microtubule would improve our representation of 
the biology, but until we add new relationship types, allowing the 
original DASH complex term to have two part_of parents is the most 
biologically accurate thing we can do.

Accordingly, I've merged the newer terms into the parent, restoring the 
part_of relationships (and removing the newer term names from the synonym 
list -- looks like nobody uses them).

midori


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