[Ontology-editors] draft has_part announcement

[David Hill]

Yup, you got it!

Midori Harris wrote:
> Yes - if you negatively regulate a negative regulation/regulator, you 
> positively regulate the target. For example, A -n.r-> B could reduce 
> production of an inhibitor, so you get less B -n.r.-> C happening, and 
> therefore more of C.
>
> m
>
> On Tue, 7 Jul 2009, Jane Lomax wrote:
>
>> Wow. Some of that seems really counterintuitive. Is this really true:
>>
>> A -neg_regulates-> B -neg_regulates-> C, then A -indirectly 
>> pos_regulates-> C
>>
>> ?
>>
>> Either way I think this merits some further discussion so we should 
>> probably leave out for now...
>>
>> Jane
>>
>>
>>
>> David Hill wrote:
>>>
>>>>
>>>>
>>>> A -regulates-> B -regulates-> C
>>>>
>>>> then
>>>>
>>>> A -indirectly regulates-> C
>>>>
>>>> ?
>>>>
>>> Yes.
>>>
>>> So here are the rules that fit when we were looking at examples from 
>>> BP. Tanya will correct me if I'm misremembering.
>>>
>>> A -regulates-> B -regulates-> C, then    A -indirectly regulates-> C
>>>
>>> A -neg_regulates-> B -neg_regulates-> C, then A -indirectly 
>>> pos_regulates-> C
>>>
>>>
>>> A -neg_regulates-> B -pos_regulates-> C, then A -indirectly 
>>> neg_regulates-> C
>>>
>>>
>>> A -pos_regulates-> B -neg_regulates-> C, then A -indirectly 
>>> neg_regulates-> C
>>>
>>>
>>> A -neg_regulates-> B -regulates-> C, then A -indirectly regulates-> C
>>>
>>>
>>> A -regulates-> B -neg_regulates-> C, then A -indirectly regulates-> C
>>>
>>>
>>> A -pos_regulates-> B -regulates-> C, then A -indirectly regulates-> C
>>>
>>>
>>> A -regulates-> B -pos_regulates-> C, then A -indirectly regulates-> C
>>
>>
>>

-- 
David P. Hill, Ph.D.
Bioinformatics Scientist: Ontology Development
Gene Ontology Consortium
The Jackson Laboratory
www.geneontology.org
www.informatics.jax.org
tel:207-288-6430